Spiral ganglion cell site of excitation I: comparison of scala tympani and intrameatal electrode responses

Hearing Research
L A CarteeC van den Honert

Abstract

To determine the site of excitation on the spiral ganglion cell in response to electrical stimulation similar to that from a cochlear implant, single-fiber responses to electrical stimuli delivered by an electrode positioned in the scala tympani were compared to responses from stimuli delivered by an electrode placed in the internal auditory meatus. The response to intrameatal stimulation provided a control set of data with a known excitation site, the central axon of the spiral ganglion cell. For both intrameatal and scala tympani stimuli, the responses to single-pulse, summation, and refractory stimulus protocols were recorded. The data demonstrated that summation pulses, as opposed to single pulses, are likely to give the most insightful measures for determination of the site of excitation. Single-fiber summation data for both scala tympani and intrameatally stimulated fibers were analyzed with a clustering algorithm. Combining cluster analysis and additional numerical modeling data, it was hypothesized that the scala tympani responses corresponded to central excitation, peripheral excitation adjacent to the cell body, and peripheral excitation at a site distant from the cell body. Fibers stimulated by an intrameatal electro...Continue Reading

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Citations

Feb 1, 2007·Journal of the Association for Research in Otolaryngology : JARO·John C Middlebrooks, Russell L Snyder
Nov 11, 2009·Journal of the Association for Research in Otolaryngology : JARO·Stephen Y KangBryan E Pfingst
Dec 25, 2009·Journal of the Association for Research in Otolaryngology : JARO·Jihwan WooPaul J Abbas
Jun 8, 2012·Journal of Neurophysiology·Joshua H GoldwynEric Shea-Brown
Jun 6, 2009·Journal of the Association for Research in Otolaryngology : JARO·Bom Jun Kwon, Chris van den Honert
Aug 7, 2014·The Journal of the Acoustical Society of America·Monita Chatterjee, Aditya M Kulkarni
Oct 27, 2015·Journal of the Association for Research in Otolaryngology : JARO·Jason BouletIan C Bruce
Jun 4, 2014·IEEE Transactions on Bio-medical Engineering·Mohamed H Negm, Ian C Bruce
Mar 24, 2009·IEEE Transactions on Bio-medical Engineering·Nikita S Imennov, Jay T Rubinstein
Apr 21, 2006·Hearing Research·Lianne A Cartee
Jul 4, 2015·Journal of the Association for Research in Otolaryngology : JARO·Robert P CarlyonColette M McKay
Mar 11, 2015·Computational and Mathematical Methods in Medicine·Soojin KangJihwan Woo
Dec 13, 2016·Journal of the Association for Research in Otolaryngology : JARO·Jason Boulet, Ian C Bruce
Jun 11, 2017·IEEE Transactions on Bio-medical Engineering·Kiran Kumar SriperumbudurUrsula van Rienen
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May 4, 2017·Journal of Neural Engineering·Andreas ProkopiouTom Francart
Aug 25, 2020·Journal of the Association for Research in Otolaryngology : JARO·François GuéritRobert P Carlyon
Jan 6, 2017·Journal of the Association for Research in Otolaryngology : JARO·Suyash Narendra JoshiBastian Epp
Jul 7, 2017·The Journal of the Acoustical Society of America·Monita Chatterjee, Aditya M Kulkarni
Dec 14, 2018·The Journal of the Acoustical Society of America·François GuéritRobert P Carlyon

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