Spiral volumetric optoacoustic tomography visualizes multi-scale dynamics in mice.

Light, Science & Applications
Xosé Luís Deán-BenDaniel Razansky

Abstract

Imaging dynamics at different temporal and spatial scales is essential for understanding the biological complexity of living organisms, disease state and progression. Optoacoustic imaging has been shown to offer exclusive applicability across multiple scales with excellent optical contrast and high resolution in deep-tissue observations. Yet, efficient visualization of multi-scale dynamics remained difficult with state-of-the-art systems due to inefficient trade-offs between image acquisition time and effective field of view. Herein, we introduce the spiral volumetric optoacoustic tomography technique that provides spectrally enriched high-resolution contrast across multiple spatiotemporal scales. In vivo experiments in mice demonstrate a wide range of dynamic imaging capabilities, from three-dimensional high-frame-rate visualization of moving organs and contrast agent kinetics in selected areas to whole-body longitudinal studies with unprecedented image quality. The newly introduced paradigm shift in imaging of multi-scale dynamics adds to the multifarious advantages provided by the optoacoustic technology for structural, functional and molecular imaging.

References

Oct 1, 1983·Journal of Pharmaceutical Sciences·L E Gerlowski, R K Jain
Jul 13, 2006·Annual Review of Biomedical Engineering·Simon R Cherry
Mar 1, 2007·Current Opinion in Critical Care·Samir G Sakka
Jul 25, 2008·Medical Image Analysis·Wolfgang WeinNassir Navab
Jan 12, 2010·Journal of Biomedical Optics·Hans-Peter BrechtAlexander A Oraevsky
Apr 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christopher M KramerFrank M Bengel
May 13, 2010·Journal of Biomedical Optics·Bradley E Treeby, B T Cox
Aug 3, 2010·Nature Methods·Vasilis Ntziachristos
Dec 17, 2010·Medical Physics·Robert A KrugerRyan P Doyle
Jan 11, 2011·Medical Image Analysis·Yipeng HuDean Barratt
Jul 2, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Daniel RazanskyVasilis Ntziachristos
Jul 9, 2011·Nature Protocols·Daniel RazanskyVasilis Ntziachristos
Aug 30, 2011·Physics in Medicine and Biology·X Luís Deán-BenVasilis Ntziachristos
May 23, 2012·Journal of Biomedical Optics·Jun XiaLihong V Wang
Jun 28, 2012·Journal of Biomedical Optics·Ben CoxPaul C Beard
Jun 28, 2012·Journal of Biomedical Optics·Chao HuangMark A Anastasio
Aug 7, 2012·Interface Focus·Paul Beard
Dec 13, 2012·Medical Physics·Jithin JoseSrirang Manohar
Jan 25, 2013·Scientific Reports·Liangzhong XiangHuabei Jiang
May 15, 2013·Physics in Medicine and Biology·Steven L Jacques
Jul 31, 2013·Physics in Medicine and Biology·X Luís Deán-BenDaniel Razansky
Sep 24, 2013·IEEE Transactions on Medical Imaging·Andreas BuehlerVasilis Ntziachristos
Nov 19, 2013·Nature Methods·Xin YuAlan P Koretsky
Nov 26, 2013·Advanced Drug Delivery Reviews·Nicolas BertrandOmid C Farokhzad
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mohammadreza NasiriavanakiLihong V Wang
Feb 4, 2014·Scientific Reports·Arie KrumholzVladislav V Verkhusha
Mar 13, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nikolaos C DeliolanisVasilis Ntziachristos
Jun 27, 2014·Chemical Society Reviews·Liming Nie, Xiaoyuan Chen
Aug 2, 2014·Nature Photonics·Adam T EggebrechtJoseph P Culver
Oct 11, 2014·Photoacoustics·Xosé Luís Deán-Ben, Daniel Razansky
Jul 23, 2015·Theranostics·Lorenz KirscherAladar A Szalay
Jul 28, 2015·Chemical Society Reviews·Jingjing LiJun-Jie Zhu
Nov 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ralph Weissleder, Matthias Nahrendorf

❮ Previous
Next ❯

Citations

Feb 1, 2019·Journal of Biophotonics·Benedict Mc LarneyDaniel Razansky
Nov 6, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Avihai RonDaniel Razansky
Nov 22, 2018·Biomedical Optics Express·Amir Rosenthal
Jan 4, 2019·Biomedical Engineering Letters·Paul Kumar Upputuri, Manojit Pramanik
Dec 18, 2019·Journal of Biophotonics·Huangxuan ZhaoChengbo Liu
Aug 2, 2017·Scientific Reports·X Luís Deán-BenDaniel Razansky
Feb 8, 2019·Light, Science & Applications·Elena MerčepDaniel Razansky
Jan 1, 2018·Optica·Ali ÖzbekDaniel Razansky
Jul 26, 2019·Physics in Medicine and Biology·Xosé Luís Deán-Ben, Daniel Razansky
Mar 10, 2017·Chemical Society Reviews·X L Deán-BenD Razansky
Dec 19, 2020·Molecular Imaging·Mucong LiJunjie Yao
Aug 21, 2019·Photoacoustics·Afreen FatimaKamran Mohammad Avanaki
Dec 24, 2019·Translational Oncology·Yonggeng GohMalini Olivo
Feb 9, 2021·Advanced Science·Huangxuan ZhaoChengbo Liu
Dec 29, 2020·Physics in Medicine and Biology·Dhiman DasManojit Pramanik
Jan 13, 2021·Reports on Progress in Physics·Chao TianYi Jin
Mar 1, 2021·The Journal of the Acoustical Society of America·Mucong LiPei Zhong
Mar 18, 2021·Journal of Biophotonics·Yihao DuanKedi Xiong
May 15, 2021·Experimental Dermatology·Xosé Luís Deán-Ben, Daniel Razansky
Jun 2, 2021·Nature Biomedical Engineering·Shuai NaLihong V Wang
Oct 25, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sheryl RobertsThomas Reiner
Aug 31, 2021·Biomedical Optics Express·Shuai Na, Lihong V Wang
Nov 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Çağla ÖzsoyDaniel Razansky
Dec 25, 2021·ACS Applied Materials & Interfaces·Sandeep Kumar KalvaDaniel Razansky
Feb 20, 2018··Hernan Lopez-SchierXosé Luís Deán-Ben

❮ Previous
Next ❯

Methods Mentioned

BETA
light scattering

Software Mentioned

SVOT
MATLAB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.