Spirochetemia due to Treponema pallidum using polymerase-chain-reaction assays in patients with early syphilis: prevalence, associated factors and treatment response

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
B-R WuC-C Hung

Abstract

Between 2009 and 2013, polymerase-chain-reaction assay was used to detect Treponema pallidum in the blood samples collected from 296 patients with early syphilis (241 being HIV infected) and 102 patients (34.5%) had spirochetemia. The presence of spirochetemia was associated with lower CD4 counts (per 10-cell/mm(3) decrease, adjusted odds ratio (AOR), 1.020; 95% CI, 1.006-1.036) and secondary syphilis (AOR, 4.967; 95% CI, 2.016-12.238). Patients with early latent syphilis were less likely to achieve serological response compared with those with primary or secondary syphilis (AOR, 0.317; 95% CI, 0.142-0.708). However, serological response was not affected by presence of spirochetemia or antibiotic regimens.

References

Oct 17, 1998·Sexually Transmitted Diseases·A PillayS A Morse
Jul 13, 2004·The New England Journal of Medicine·Sheila A LukehartJeffrey D Klausner
Jan 19, 2006·Clinical Microbiology Reviews·Rebecca E Lafond, Sheila A Lukehart
Sep 28, 2010·The Journal of Infectious Diseases·Christina M MarraSheila A Lukehart
Jan 6, 2012·Journal of Clinical Microbiology·P A GrangeN Dupin

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Citations

Dec 9, 2014·Current Opinion in Infectious Diseases·Craig Tipple, Graham P Taylor
Dec 30, 2014·Current Opinion in Infectious Diseases·David LawrenceMartin Fisher
Oct 31, 2020·Chinese Medical Journal·Xiao-Ke LiuJun Li
Dec 5, 2020·Chinese Medical Journal·Xiao-Ke LiuJun Li
Feb 16, 2019·Médecine et maladies infectieuses·Carole EldinDidier Raoult

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