PMID: 418179Apr 1, 1978

Spiro[isobenzofuran-1(3H),4'-piperidines]. 3. Diuretic and antihypertensive properties of compounds containing a sulfur attached to nitrogen

Journal of Medicinal Chemistry
S S Klioze, W J Novick


The synthesis and antihypertensive and diuretic activity of several N-sulfur derivatives of 3-phenylspiro[isobenzofuran-1(3H),4'-piperidine] are reported. Benzenesulfenamide 3 possessed marked, species-specific diuretic and antihypertensive activity in rats.

Related Concepts

Antihypertensive Agents
Depression, Chemical
Diuretic Effect
Canis familiaris
Hypertensive Disease
Macaca mulatta

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