Spirometric-gated computed tomography quantitative evaluation of lung emphysema in chronic obstructive pulmonary disease: a comparison of 3 techniques

Journal of Computer Assisted Tomography
Ilaria OrlandiMario Mascalchi

Abstract

To compare the quantitative assessment of pulmonary emphysema with spirometric-gated computed tomography (gated CT) using 3 different acquisition techniques and to determine if low-current spiral CT could be used effectively to quantitate emphysema. Eleven patients with chronic obstructive pulmonary disease (COPD) underwent gated CT and pulmonary function tests (PFTs). Spiral whole-lung 10-mm collimation acquisitions at standard (146 mAs) and low (43 mAs) current and sequential 3-slice 1-mm collimation high-resolution computed tomography (HRCT) acquisitions at standard current were obtained at 90% of the patient's vital capacity. The mean lung density (MLD) and the pixel index (PI) derived from the 3 data sets were compared using one-way analysis of variance and correlated with PFTs using linear regression. Moreover, the radiation dose associated with each technique was measured. The MLDs were not significantly different. The PIs calculated from the standard- and low-current spiral acquisitions were similar, and both were significantly different from that of HRCT. The MLDs correlated with the PFTs in standard-current spiral and HRCT but not in low-current spiral acquisitions, whereas the PIs correlated with the PFTs in all 3 te...Continue Reading

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Citations

Aug 26, 2009·European Radiology·Massimo BellomiPatrick Maisonneuve
Oct 2, 2012·Respiratory Investigation·Nguyen Van ThoYasutaka Nakano
Sep 7, 2006·Journal of Computer Assisted Tomography·Ilaria OrlandiMario Mascalchi
Feb 28, 2008·Current Opinion in Pulmonary Medicine·Hisamitsu OmoriTakahiko Katoh
Aug 3, 2010·Respiratory Medicine·Elisabeth BernspångEeva Piitulainen
Jan 24, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Riccarda FailoMaarten H Lequin
Jun 17, 2006·Journal of Computer Assisted Tomography·Julia ZaporozhanHans-Ulrich Kauczor

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