PMID: 9179708Jun 1, 1997Paper

Spirometric gated quantitative computed tomography of the lung in healthy smokers and nonsmokers

Investigative Radiology
D PelinkovicR Buhl

Abstract

The authors investigated the influence of cigarette smoking on healthy, asymptomatic smokers and nonsmokers with the help of spirometric triggered quantitative computed tomography. In our prospective study, the authors compared conventional lung function parameters with the computed tomography values (lung attenuation, lung area). The study group comprised 40 healthy volunteers consisting of 20 smokers and nonsmokers (20 females and 20 males). The corresponding groups have been matched concerning their age, height, body mass, (cigarette) pack years. Computer tomography scans were triggered at 35%, 50%, 70% and 95% of vital capacity at a defined apical and a basal level. Functional residual capacity (FRC), total lung capacity and airway resistance showed close correlations to lung parenchymal attenuation values especially at full inspiration and expiration. For example, the authors found a correlation coefficient of r = -0.845 (P < or = 0.001) concerning the FRC and lung attenuation values in the apical lung at 35% of vital capacity in male smokers. Male smokers proved to have a significantly higher pulmonary lung density at all inspiratory states than the other groups (P < or = 0.05; Student's t test). Although male smokers had...Continue Reading

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Citations

Feb 24, 2004·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Donald W McRobbieRebecca A Quest
Jun 1, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Risa J RobinsonJohn N Diflorio
Jul 16, 2005·Experimental Lung Research·Andrew HoffmanEdward Ingenito

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