Spironolactone is associated with reduced risk of new-onset atrial fibrillation in patients receiving renal replacement therapy

International Journal of Cardiology
Yi-Wei ChungJiunn-Lee Lin

Abstract

Whether the spironolactone treatment remains effective for the prevention of atrial fibrillation (AF) in dialysis patients is unclear. We used a database from the Registry for Catastrophic Illness from the National Health Research Institute. All dialysis patients aged 18 or older without history of AF before ESRD were incorporated. A total of 113,191 dialysis patients were enrolled in the study. The median follow-up time was 4.17 years. We collected information on prescribed drug dosage, number of days of treatment and the total number of pills dispensed from the outpatient pharmacy prescription database. All individuals in the study cohort with the first occurrence of AF were included as cases. In spironolactone group, the incidence of developing new AF was significantly lower than that in the control group both before (0.8% vs. 3.3%, P=0.019) and after PS matching (1.2% vs. 3.0%, P=0.019). Before PS matching, Cox's proportional hazard regression analyses showed that spironolactone was associated with 60% reduction of new AF (HR=0.372 [0.200-0.692], P=0.002) and the protective effect is dose-responsive in accumulated dose, treatment duration and mean daily dose. After PS matching, the overall AF prevention effect remained sign...Continue Reading

References

Feb 6, 1997·Health Policy·T L Chiang
Mar 29, 2001·American Journal of Nephrology·M WiesholzerP Balcke
Jun 13, 2001·JAMA : the Journal of the American Medical Association·B F GageM J Radford
May 22, 2003·Health Affairs·Jui-Fen Rachel Lu, William C Hsiao
Apr 20, 2005·Journal of the American College of Cardiology·Paul MilliezJean-Jacques Mourad
Feb 3, 2007·Cardiovascular Research·Akiko Shiroshita-TakeshitaStanley Nattel
Jun 30, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Chih-Sheng LinShoei K Stephen Huang
Aug 28, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Meghan J ElliottRachel M Holden
Feb 26, 2008·Journal of the American College of Cardiology·Brett Burstein, Stanley Nattel
Dec 3, 2008·International Journal of Cardiology·Kuo-Liong ChienYuan-Teh Lee
Jan 3, 2009·Journal of the American College of Cardiology·Fabio BelluzziStefano Perlini
Mar 20, 2009·Journal of the American Society of Nephrology : JASN·Kevin E ChanRaymond M Hakim
Aug 29, 2009·Journal of the American Society of Nephrology : JASN·Kevin E ChanRaymond M Hakim
Feb 23, 2010·Journal of the American College of Cardiology·Chia-Ti TsaiJiunn-Lee Lin
Jun 5, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Antonio VukusichElisa T Marusic
Jun 16, 2011·Clinical Cardiology·Ryan S WilliamsR Haris Naseem
Nov 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Deborah ZimmermanCatherine M Clase
Nov 5, 2013·Journal of the American College of Cardiology·Yoshihiro MatsumotoNobuo Shio
Jul 18, 2014·Expert Opinion on Pharmacotherapy·Sandra D BrowneSultan Ahmed
Aug 20, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·V SimopoulosI Aidonidis

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Citations

Apr 30, 2017·Current Hypertension Reports·Radmila Lyubarova, Elvira O Gosmanova
May 20, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi Morimoto, Atsuhiro Ichihara
Sep 8, 2018·American Journal of Hypertension·Mathieu BuonafineFrédéric Jaisser
Jul 29, 2021·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·A LaskaryM L O'Sullivan

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