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Spironolactone metabolism in man studied by gas chromatography-mass spectrometry

Drug Metabolism and Disposition : the Biological Fate of Chemicals

Jan 1, 1975

Anwarul KarimL J Chinn

PMID: 1221

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Abstract

Gas chromatography-mass spectrometry was used to identify metabolites of spironolactone in human blood and urine. In three healthy men about 20% of the radioactivity was excreted in the urine within 24 hr after an oral dose of [20-3H]spironolactone (200 mg + 200 muCi). About half of thi...read more

Mentioned in this Paper

Soluble
Sulfoxides
Gas Chromatography-Mass Spectrometry
Canrenoate
Spironolactone
Chloroform
Infrared Spectrophotometry
Portion of Urine
Sulfhydryl Compounds
PH.3
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  • Spironolactone metabolism in man studied by gas chromatography-mass spectrometry

    Drug Metabolism and Disposition : the Biological Fate of Chemicals

    Jan 1, 1975

    Anwarul KarimL J Chinn

    PMID: 1221

    DOI:

    Abstract

    Gas chromatography-mass spectrometry was used to identify metabolites of spironolactone in human blood and urine. In three healthy men about 20% of the radioactivity was excreted in the urine within 24 hr after an oral dose of [20-3H]spironolactone (200 mg + 200 muCi). About half of thi...read more

    Mentioned in this Paper

    Soluble
    Sulfoxides
    Gas Chromatography-Mass Spectrometry
    Canrenoate
    Spironolactone

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