PMID: 7036914Dec 1, 1981Paper

Spironolactone therapy in infants with congestive heart failure secondary to congenital heart disease

Archives of Disease in Childhood
S M HobbinsA G Korey

Abstract

The efficacy of treatment with spironolactone for congestive heart failure secondary to congenital heart disease was studied in 21 infants under 1 year of age. All received digoxin and chlorothiazide. In addition, group A (n = 10) was given supplements of potassium and group B (n = 11) received spironolactone. Daily clinical observations of vital signs, weight, hepatomegaly, and vomiting were recorded. Paired t test analysis showed significant reduction in liver size and weight (P less than 0.01) and respiratory rate (P less than 0.05) in group B, and less significant decreases in group A. The incidence of vomiting was slightly lower in group B. We conclude that the addition of spironolactone hastens and enhances the response to standard treatment with digoxin and chlorothiazide in infants with congestive heart failure.

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Citations

Aug 11, 2006·Paediatric Drugs·Maria M J van der VorstJacobus Burggraaf
Jan 24, 1986·The American Journal of Cardiology·M K WitteJ L Blumer
Feb 14, 2006·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·D S Semama
Apr 7, 2005·The Annals of Pharmacotherapy·Marcia L Buck
Dec 27, 2005·Expert Review of Cardiovascular Therapy·Hans Henrik Odland, Erik M D Thaulow
Apr 7, 2017·Journal of Clinical Pharmacy and Therapeutics·B S MoffettP A Checchia
Aug 5, 2016·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Eric L WaldConrad L Epting
Feb 23, 2021·Global Pediatric Health·Renjithkumar Kalikkot ThekkeveeduPradeep Alur

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