PMID: 6159454Jan 1, 1980Paper

Spiroperidol binding in the human caudate nucleus

Journal of Neural Transmission. Supplementum
M H WinklerM D Yahr

Abstract

The displacement of spiroperidol binding by the optical isomers of butaclamol in synaptosomal preparations of the caudate nucleus obtained from parkinsonians and non-parkinsonians at post mortem were investigated. A group of spiroperidol binding sites found in the non-parkinsonians was less strongly expressed or absent in analogous tissue of the parkinsonian. The significance of these findings in relation to Parkinson's disease and its treatment are discussed.

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