PMID: 2500774Jan 1, 1989Paper

Spitz nevus (large spindle cell and/or epithelioid cell nevus). Age-related involvement of the suprabasal epidermis

Virchows Archiv. A, Pathological Anatomy and Histopathology
Y Mérot, E Frenk

Abstract

The Spitz nevus (large spindle and/or epithelioid cell nevus) is a benign acquired melanocytic tumour found predominantly in children and adolescents. Depending on the architecture (junctional, compound, dermal) and cytology (predominance of spindle or epithelioid cells, or presence of both cell types) several variants have been distinguished. A histological feature occasionally leading to diagnostic difficulties is the involvement of the suprabasal epidermis. The present study details the occurrence of intraepidermal involvement (pagetoid spread, nesting of cells, trans-epidermal elimination) according to the age of the patients. 89 cases of Spitz nevus were reviewed. There were 19 compound Spitz nevi with evidence of epidermal involvement, 56 cases of compound Spitz nevi without evidence of epidermal involvement and 14 cases of dermal Spitz nevi. The epidermal involvement mainly consisted of nesting of nevus cells above the basal cell layer, 9 cases clearly showing evidence of transepidermal elimination of cell nests. Upward spread of single melanocytes (pagetoid spread) was minimal and always associated with nesting or trans-epidermal elimination. The mean age of patients was significantly lower in the group of compound nevi...Continue Reading

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Citations

Jul 22, 2009·Archives of Dermatology·Iris ZalaudekGiuseppe Argenziano
Dec 23, 1999·The American Journal of Dermatopathology·A SpatzR L Barnhill
Feb 4, 2006·The American Journal of Dermatopathology·Raymond L Barnhill
May 1, 1993·International Journal of Dermatology·C B KoH P Bury
May 1, 1994·International Journal of Dermatology·A ItamiA Kukita
Oct 6, 2009·Annales de dermatologie et de vénéréologie·H NojavanD R Mehregan
Jun 20, 2002·Advances in Anatomic Pathology·Wolter J Mooi
Feb 1, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Raymond L Barnhill
Mar 14, 2018·The American Journal of Dermatopathology·Oscar W Nevares-PomalesFrancisco Colon-Fontanez
Nov 30, 2005·The American Journal of Dermatopathology·Anna Maria CesinaroGian Paolo Trentini
Mar 26, 2009·The American Journal of Dermatopathology·Celia RequenaEvaristo Sánchez Yus
Jan 9, 2019·Frontiers in Medicine·Lisa M HillenVéronique Winnepenninckx
Oct 21, 2016·Journal of Cutaneous Pathology·Anthony P FernandezMelissa P Piliang
Feb 4, 2012·Journal of the American Academy of Dermatology·Maya ZayourRossitza Lazova

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