PMID: 9449488Feb 4, 1998Paper

Spitz's nevi with halo reaction: a histopathologic study of 17 cases

Journal of Cutaneous Pathology
Jeff D HarvellPhilip E LeBoit

Abstract

Halo reactions to melanocytic nevi are a well-recognized phenomenon. In contrast, halo reactions to Spitz's nevi have been reported only infrequently. Halo reactions may cause misdiagnosis of an otherwise benign nevus as melanoma because inflammatory cells sometimes obscure the architectural features of the underlying nevus, and may induce cytologic atypia. For Spitz's nevus where the distinction between malignancy and benignancy is already challenging, halo reactions compound the problem. We describe 17 examples of Spitz's nevus with halo reaction, and compare their immunohistochemical features with those of "ordinary" halo nevi. Only 2 of 17 lesions demonstrated clinically apparent halos. Clinical follow-up was available for 12 of 17 cases. None of the 12 has persisted at the biopsy site or metastasized after an average 3.6-year follow-up period. Junctional, compound, intradermal, and combined types of Spitz's nevi were represented. All were characterized by symmetrical lymphocytic infiltrates which permeated the full thickness of the nevus, including junctional nests. Combined Spitz's nevi constituted more than one-half of examples in this series (9/17 cases). The combined Spitz's nevus included a combination of Spitz's nevu...Continue Reading

References

Dec 1, 1991·The American Journal of Surgical Pathology·D R PulitzerR J Reed
Jan 1, 1990·The American Journal of Surgical Pathology·R J ReedW H Clark
Dec 20, 1989·Journal of the National Cancer Institute·W H ClarkA C Halpern
Apr 1, 1989·Journal of Cutaneous Pathology·B R SmollerA Hsu
Nov 1, 1988·European Journal of Pediatrics·M G BialerW G Wilson
Jan 1, 1985·The American Journal of Dermatopathology·G S RogersA B Ackerman
Jul 1, 1968·Cancer·D M Wayte, E B Helwig
Apr 1, 1981·The Journal of Pathology·H M Cameron, E McGoogan
Oct 1, 1995·The American Journal of Dermatopathology·N YasakaK Tamaki
Dec 1, 1995·Journal of Cutaneous Pathology·N S McNuttJ Lugo
Jul 1, 1965·Archives of Dermatology·A W KopfI Silberberg
Jan 1, 1990·Veterinary Clinical Pathology·David A. Williams, Scott D. Reed

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Citations

Dec 4, 2004·The American Journal of Surgical Pathology·Markus HantschkePhilip E LeBoit
Jun 20, 2002·Advances in Anatomic Pathology·Wolter J Mooi
Nov 30, 2005·The American Journal of Dermatopathology·Anna Maria CesinaroGian Paolo Trentini
Mar 26, 2009·The American Journal of Dermatopathology·Celia RequenaEvaristo Sánchez Yus
Jun 16, 2012·The American Journal of Dermatopathology·Angel Fernandez-Flores
Jul 17, 1999·Journal of Cutaneous Pathology·S Kabukçuoğlu, N S McNutt
Jun 3, 2005·Clinical Medicine & Research·Ilene B Bayer-GarnerJaime A Tschen
May 6, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Nicola ArpaiaGino Antonio Vena
Jan 31, 2017·The American Journal of Dermatopathology·Angel Fernandez-FloresJosé Luis Rodriguez-Peralto
Dec 17, 2016·Seminars in Diagnostic Pathology·Mark R WickAlejandro A Gru
Apr 3, 2002·International Journal of Surgical Pathology·B ClarkeR Chetty
Mar 15, 2018·The American Journal of Surgical Pathology·Katharina WiedemeyerThomas Brenn
Apr 8, 2014·The American Journal of Surgical Pathology·Iwei YehPhilip E LeBoit
Jul 27, 2007·Virchows Archiv : an International Journal of Pathology·Guido Massi
Mar 24, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Carlo TomasiniMario Pippione
Mar 13, 2009·Journal of Cutaneous Pathology·Michael T TetzlaffRosalie Elenitsas
Jul 10, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·S AmicoJ Seneschal
Feb 26, 2020·Journal of Cutaneous Pathology·Lyn M Duncan, Michael T Tetzlaff
Oct 30, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Iwei Yeh
Sep 26, 2003·Journal of Cutaneous Pathology·Mai P Hoang
Sep 19, 2012·Journal of Cutaneous Pathology·Vicente Sabater MarcoRafael Botella Estrada
Apr 17, 2014·The American Journal of Dermatopathology·Jose A PlazaDmitry V Kazakov
Apr 3, 2018·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Chen YangLouis P Dehner
Dec 20, 2011·Histopathology·Thomas Brenn
Nov 14, 2020·Journal of Cutaneous Pathology·Kristen N RubyShaofeng Yan

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