Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice

Gastroenterology
Stuart M BrierleyL Ashley Blackshaw

Abstract

Mechanosensory information from the colon is conducted via lumbar splanchnic nerves (LSN) and sacral pelvic nerves (PN) to the spinal cord. The precise nature of mechanosensory information encoded by each pathway has remained elusive. Here, we characterize and directly compare the properties of mechanosensitive primary afferents from these 2 pathways. Using a novel in vitro mouse colon preparation, mechanosensitive primary afferents were recorded from the LSN and PN and distinguished based on their response to receptive field stimulation with 3 distinct mechanical stimuli: probing (70 mg-4 g), circular stretch (1-5 g), and mucosal stroking (10-1000 mg). Five different classes of afferent were recorded from the LSN and PN. Three of these classes of afferent (serosal, muscular, and mucosal) were conserved between both pathways; however, their respective proportions, receptive field distributions, and response properties differed greatly. In general, these 3 classes of afferent recorded from the PN responded to lower stimulation intensities, displayed greater response magnitudes, and adapted less completely to mechanical stimulation compared with their LSN counterparts. In addition, the LSN and PN each contain a specialized class ...Continue Reading

References

Jul 1, 1976·The Journal of Physiology·K FloydJ F Morrison
Oct 1, 1987·Pflügers Archiv : European journal of physiology·E BahnsW Jänig
Feb 1, 1986·Journal of the Autonomic Nervous System·R BahrW Jänig
Oct 1, 1974·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·K Floyd, J F Morrison
Jun 1, 1983·Pflügers Archiv : European journal of physiology·H BlumbergW Kohler
Jun 1, 1983·Pflügers Archiv : European journal of physiology·P HauptW Kohler
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·A M BrunsdenD Grundy
Nov 2, 2002·The Journal of Physiology·Gareth A HicksL Ashley Blackshaw

❮ Previous
Next ❯

Citations

Oct 16, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Ewan St John Smith, Gary R Lewin
Jul 14, 2011·Nature Reviews. Neuroscience·Emeran A Mayer
Nov 19, 2008·Molecular Interventions·David R Robinson, G F Gebhart
Aug 4, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bin FengG F Gebhart
Aug 4, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jun-Ho LaG F Gebhart
Sep 26, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pablo Rodolfo BrumovskyG F Gebhart
Nov 13, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bin Feng, G F Gebhart
Apr 23, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jun-Ho La, G F Gebhart
Jan 5, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·T TanakaG F Gebhart
Jan 16, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bin FengGerald F Gebhart
Jan 24, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bin FengG F Gebhart
Aug 30, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·P A LynnS J H Brookes
Jan 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sacha A MalinBrian M Davis
Jun 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bin FengGerald F Gebhart
Dec 22, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·De-bo Qi, Wei-min Li
Dec 19, 2013·ISRN Neurology·Pablo R Brumovsky
Aug 26, 2010·Pharmaceuticals·Stuart M BrierleyL Ashley Blackshaw
Jul 24, 2013·Expert Review of Gastroenterology & Hepatology·L Ashley Blackshaw, Stuart M Brierley
Dec 2, 2006·The Journal of Physiology·Jonathan R ColdwellL Ashley Blackshaw
Oct 6, 2007·The Journal of Physiology·Vladimir P ZagorodnyukSarah J Gregory
Feb 7, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J Fioramonti, G F Gebhart
Jun 11, 2005·The Journal of Physiology·Stuart M BrierleyL Ashley Blackshaw
Nov 13, 2012·Gastroenterology·John H Winston, Sushil K Sarna
Oct 16, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M A CampanielloP A Hughes
Aug 18, 2009·Autonomic Neuroscience : Basic & Clinical·Stuart M Brierley
Aug 18, 2009·Autonomic Neuroscience : Basic & Clinical·Vladimir P ZagorodnyukNick J Spencer
Jul 28, 2009·Gastroenterology·Stuart M BrierleyL Ashley Blackshaw
May 2, 2009·Neuroscience Letters·Benjamin D PhillisL Ashley Blackshaw
Mar 3, 2009·Cellular Signalling·Christopher P Gayer, Marc D Basson
Jan 20, 2009·Brain Research Reviews·Julie A ChristiansonNathalie Vergnolle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.