Splanchnic haemodynamics in non-alcoholic fatty liver disease: effect of a dietary/pharmacological treatment. A pilot study

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Donatella MagalottiMarco Zoli

Abstract

Previous studies demonstrated that in experimental animals fatty liver is associated with reduced hepatic blood flow and that metformin reverses steatosis, while no data were reported in humans. To evaluate the clinical relevance of echo-Doppler measurements and the effects of therapy in non-alcoholic fatty liver disease. Twenty patients with biopsy proven non-alcoholic fatty liver disease. Abdominal echo-Doppler examination was performed at enrolment and, in 11 patients, after 6 months of dietary/pharmacological therapy (metformin 500 mg three times a day). Non-alcoholic fatty liver disease was characterised by hepatomegaly, bright echotexture and posterior attenuation. Mean portal blood velocity and flow were low-normal. Brightness and posterior attenuation significantly correlated with fat score in liver biopsies as well as with the hepatic veins spectrum. After therapy, echotexture improved and liver volume significantly decreased. Portal blood velocity and flow significantly increased, intrahepatic arterial indexes decreased and the spectrum of hepatic veins improved. Fatty liver is associated with an impaired hepatic blood flow characterised by increased intrahepatic resistances. Vascular changes are reversed by treatment...Continue Reading

References

Oct 1, 1991·Clinical Radiology·A E Joseph, S H Saverymuttu
Apr 1, 1986·AJR. American Journal of Roentgenology·F MoriyasuH Uchino
Jul 1, 1980·AJR. American Journal of Roentgenology·W W ScottS S Siegelman
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C SabbàL Bolondi
Feb 11, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A M SeifalianB R Davidson
May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Oct 9, 1999·Transplantation·A M SeifalianB R Davidson
Nov 24, 1999·The American Journal of Medicine·G MarchesiniN Melchionda
Jun 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D G FongA L Buchman
Jul 27, 2001·Diabetes·G MarchesiniN Melchionda
Aug 8, 2001·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·A M SeifalianB R Davidson
Sep 25, 2001·Lancet·G MarchesiniN Melchionda
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiJanus P Ong
Sep 19, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·U L MathiesenG Bodemar
Jan 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Elizabeth M BruntAdrian M Di Bisceglie

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Citations

May 9, 2006·Postgraduate Medical Journal·L A Adams, P Angulo
Jul 17, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Tianrun LiBing Dong
Mar 30, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Leon A AdamsKeith D Lindor
Oct 21, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Sven FrancquePeter Michielsen
Jul 7, 2015·Journal of Diabetes and Metabolic Disorders·Peyman LotfiAzadeh Ebrahim-Habibi
Jul 30, 2014·Frontiers in Public Health·Héctor J Finol, Antonio Roschman-González
Apr 26, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Daniela CatalanoAntonia Tonzuso
Mar 11, 2020·Frontiers in Endocrinology·Chelsea S Pan, Takara L Stanley

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