PMID: 8588334Nov 1, 1995Paper

Spleen and kidney of Atlantic salmon (Salmo salar L.) show histochemical changes early in the course of experimentally induced infectious salmon anaemia (ISA)

Veterinary Immunology and Immunopathology
Knut FalkB H Dannevig

Abstract

Infectious salmon anaemia (ISA) is a disease of farmed Atlantic salmon (Salmo salar L.) in Norway that affects both erythrocytic and leucocytic cells. Both cell types are possible target cells for the aetiological ISA agent, which is probably a virus. In the present study the distribution and phenotype of leucocyte populations in the spleen and head kidney of Atlantic salmon that were developing ISA have been examined. Frozen tissues were collected from fish at various times after inoculation with ISA-infective material. Immune and enzyme histochemical techniques were used to characterise the response of leucocyte populations. Acid phosphatase positive macrophages predominantly in the red pulp of the spleen appeared to have engulfed erythrocytes at day 4 after infection. Evidence of degradation products of phagocytosed erythrocytes was present in macrophages in red pulp of the spleen at day 7 after infection, in addition to the usual site of erythrophagocytosis in melanomacrophage accumulations. Signs of erythrophagocytosis were not found in the head or body portions of the kidney. The activation of macrophages in the spleen at day 7 was suggested by decreased reactivity for the enzyme 5' nucleotidase. From day 7, clusters of i...Continue Reading

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Citations

Aug 29, 2013·Developmental and Comparative Immunology·Bertrand Collet
Oct 29, 2010·Virus Research·Luis CottetEugenio Spencer
Jun 14, 2005·Fish & Shellfish Immunology·Bergljót Magnadóttir
Jan 5, 2019·Current Pharmaceutical Design·Thea MagroneEmilio Jirillo
Jun 18, 2003·The Journal of General Virology·Tomy JosephFrederick S B Kibenge
Sep 28, 2004·The Journal of General Virology·Tomy JosephFrederick S B Kibenge
Aug 5, 2017·Frontiers in Immunology·Natalie C Steinel, Daniel I Bolnick

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