PMID: 6112711May 14, 1981Paper

Spleen colony-forming cell as common precursor for tissue mast cells and granulocytes

Nature
Y KitamuraK J Mori

Abstract

The haematopoietic stem cells which produce colonies in the spleen of irradiated mice (CFU-S) can differentiate into erythrocytes, granulocytes, megakaryocytes and B lymphocytes. Although mast cell precursors are known to be present in the bone marrow, spleen, fetal liver and peripheral blood of mice, the relationship between the mast cell precursor and CFU-S has remained unclear. We have now made use of mice of two mutant genotypes to determine whether or not the tissue mast cell is a progeny of CFU-S. Giant granules of beige (C57BL/6-bg/bg, Chediak-Higashi syndrome) mice can be used for identification of the origin of both tissue mast cells and granulocytes, and WBB6F1-W/Wv mice are useful recipients because they lack tissue mast cells owing to a defect in mast cell precursors. We injected the cells from a single spleen colony into each WBB6F1-W/Wv mouse and demonstrated directly that the tissue mast cell is a progeny of CFU-S.

References

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Citations

Nov 9, 2000·European Journal of Immunology·B RuppA K Werenskiold
Jun 4, 2002·International Journal of Hematology·Tatsutoshi Nakahata, Hano Toru
May 5, 2011·Basic Research in Cardiology·Santosh K SanganalmathBuddhadeb Dawn
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Sep 1, 2007·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Yukihiko KitamuraAkihiko Ito
Feb 4, 2014·Pharmacology & Therapeutics·Laurent L Reber, Nelly Frossard
Jul 24, 2008·Journal of Gastroenterology·Yukihiko Kitamura
Jun 17, 2008·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Akihiko ItoJunko Oonuma

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