Spleen Size and Function in Sherpa Living High, Sherpa Living Low and Nepalese Lowlanders

Frontiers in Physiology
Pontus HolmströmErika Schagatay

Abstract

High-altitude (HA) natives have evolved some beneficial responses leading to superior work capacity at HA compared to native lowlanders. Our aim was to study two responses potentially protective against hypoxia: the spleen contraction elevating hemoglobin concentration (Hb) and the cardiovascular diving response in Sherpa highlanders, compared to lowlanders. Male participants were recruited from three groups: (1) 21 Sherpa living at HA (SH); (2) seven Sherpa living at low altitude (SL); and (3) ten native Nepalese lowlanders (NL). They performed three apneas spaced by a two-min rest at low altitude (1370 m). Their peripheral oxygen saturation (SpO2), heart rate (HR), and spleen volume were measured across the apnea protocol. Spleen volume at rest was 198 ± 56 mL in SH and 159 ± 35 mL in SL (p = 0.047). The spleen was larger in Sherpa groups compared to the 129 ± 22 mL in NL (p < 0.001 compared to SH; p = 0.046 compared to SL). Spleen contraction occurred in all groups during apnea, but it was greater in Sherpa groups compared to NL (p < 0.001). HR was lower in Sherpa groups compared to NL both during rest (SL: p < 0.001; SH: p = 0.003) and during maximal apneas (SL: p < 0.001; SH: p = 0.06). The apnea-induced HR reduction was 8...Continue Reading

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Citations

Sep 11, 2020·European Journal of Applied Physiology·Erika SchagatayAngelica Lodin-Sundström
Mar 9, 2021·European Journal of Applied Physiology·Angelica Lodin-SundströmErika Schagatay
Jun 25, 2021·Journal of Applied Physiology·Pontus K HolmströmErika K Schagatay

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