Spleen stiffness is positively correlated with HVPG and decreases significantly after TIPS implantation

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Matthias BuechterAlisan Kahraman

Abstract

Transjugular intrahepatic portosystemic shunt (TIPS) is indicated in patients with decompensated portal hypertension (PH). Hepatic venous pressure gradient (HVPG) is considered gold standard for assessment of PH. Because HVPG measurement is invasive, non-invasive methods for evaluating severity of PH are warranted. We retrospectively correlated spleen stiffness as measured by FibroScan with HVPG in patients who underwent TIPS. Twenty-four patients with spleen stiffness measurement (SSM) one day before (D-1), one day after (D+1) and 28 days after TIPS (D+28) were included. SSM was positively correlated with pre-TIPS HVPG (HVPG <13mmHg, median SSM: 19.7±8.6kPa; HVPG 13-24mmHg, median SSM: 45.0±15.7kPa; HVPG >24mmHg, median SSM: 75.0±6.2kPa; p<0.05]; r2=0.72; p<0.001) and decreased significantly after TIPS implantation (D-1, median SSM: 67.1±17.3kPa; D+1, median SSM: 44.7±18.5kPa; D+28, median SSM: 35.6±17.0kPa; p<0.05), while liver stiffness measurement decrease was not statistically significant. Our study highlights the utility of SSM as non-invasive tool in patients with chronic liver disease in evaluating degree of PH potentially offering a confirmable additional parameter in surveillance of patients undergoing TIPS procedure.

Citations

Jun 20, 2020·Seminars in Liver Disease·Mattias MandorferThomas Reiberger
Sep 15, 2020·Abdominal Radiology·Paul KennedyBachir Taouli
Oct 23, 2018·Scandinavian Journal of Gastroenterology·D S KaragiannakisJ Vlachogiannakos
Jul 16, 2020·BMJ Open Gastroenterology·Maria EffenbergerHerbert Tilg
Nov 20, 2020·Journal of Hepatology·Nicolas GolseIrene E Vignon-Clementel
Mar 30, 2021·Hepatic Medicine : Evidence and Research·Elton DajtiFrancesco Azzaroli
Apr 12, 2021·Clinics in Liver Disease·Élise Vuille-LessardAnnalisa Berzigotti

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