PMID: 6969421Jan 1, 1980Paper

Spleen white pulp architecture in the assessment of immunity in patients with far-advanced pancreatic carcinoma

Scandinavian Journal of Gastroenterology
K Syrjänen

Abstract

The histological changes in the white pulp of the spleens collected from 63 patients who had died of widespread adenocarcinoma of the pancreas were assessed by a standardized reporting system. As control material served the same number of age- and sex-matched patients who had died of myocardial infarction without signs of any malignancy. Special attention was focused on the evaluation of the lymphocyte populations (T- and B-cell areas) responsible for immunological reactivity. Histological characteristics suggested to reflect the activity of both cell-mediated and humoral immune responses were within normal limits in the control patients, whereas in the carcinoma series both the T- and B-cell areas were profoundly depleted. The results were interpreted, although with caution, to suggest that some degree of impairment of both humoral and cell-mediated immunity probably exists in patients dying of widespread carcinoma of the pancreas.

References

Jan 1, 1979·Scandinavian Journal of Urology and Nephrology·K J Syrjänen
Jan 1, 1977·Scandinavian Journal of Gastroenterology·K J Syrjänen, L H Hjelt
May 1, 1976·Cellular Immunology·P Nieuwenhuis, W L Ford
Jun 8, 1974·Lancet·J A Habeshaw, A E Stuart
Sep 1, 1965·The Journal of Experimental Medicine·P Gold, S O Freedman
Apr 1, 1965·Experimental and Molecular Pathology·H Z MOVAT, N V FERNANDO

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