Abstract
Acute splenic sequestration crises are a complication of sickle cell disease, with high mortality rates and frequent recurrence in survivors of first attacks. Splenectomy and blood transfusion, with their consequences, are the mainstay of long-term management used in different parts of the world. This is a 2015 update of a Cochrane review first published in 2002, and previously updated in 2013. To assess whether splenectomy (total or partial), to prevent acute splenic sequestration crises in people with sickle cell disease, improved survival and decreased morbidity in people with sickle cell disease, as compared with regular blood transfusions. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Haemoglobinopathies Trials Register, which comprises of references identified from comprehensive electronic database searches and handsearching relevant journals and abstract books of conference proceedings.Additional trials were sought from the reference lists of the trials and reviews identified by the search strategy.Date of the most recent search: 10 June 2015. All randomized or quasi-randomized controlled trials comparing splenectomy (total or partial) to prevent recurrence of acute splenic sequestration crises wit...Continue Reading
References
Aug 1, 1992·European Journal of Haematology·A PincaC Vullo
Feb 1, 1992·Journal of Pediatric Surgery·R W PowellV N Mankad
Jan 1, 1992·The Journal of Pediatrics·A I Airede
Aug 1, 1990·The Journal of Pediatrics·T R KinneyH C Filston
Mar 1, 1989·Blood Reviews·S C Davies, M Brozović
Aug 1, 1985·The Journal of Pediatrics·A M EmondG R Serjeant
Jan 14, 1984·Lancet·A M EmondG R Serjeant
Jul 5, 1984·The New England Journal of Medicine·O S PlattM A Espeland
Oct 1, 1981·Archives of Disease in Childhood·J M TopleyG R Serjeant
Feb 17, 1996·BMJ : British Medical Journal·UNKNOWN Working Party of the British Committee for Standards in Haematology Clinical Haematology Task Force
Aug 29, 1998·Journal of Pediatric Surgery·O Idowu, A Hayes-Jordan
Mar 4, 1999·The Journal of Pediatrics·J G WrightG R Serjeant
Oct 19, 1999·Journal of Pediatric Hematology/oncology·A H Al-SalemY M Yassin
Jan 10, 2003·The Cochrane Database of Systematic Reviews·S Owusu-Ofori, C Riddington
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Dec 1, 1945·Transactions of the Royal Society of Tropical Medicine and Hygiene·R W EVANS
Jun 4, 2013·The Cochrane Database of Systematic Reviews·Shirley Owusu-Ofori, Ceri Hirst