Splenic gammadelta T cells regulated by CD4+ T cells are required to control chronic Plasmodium chabaudi malaria in the B-cell-deficient mouse.

Infection and Immunity
Henri van der HeydeWilliam P Weidanz

Abstract

Little is known about the function and regulation of splenic gammadelta T cells during chronic Plasmodium chabaudi malaria. The splenic gammadelta T-cell population continues to expand, reaching levels equal to 4 times the number of splenocytes in an uninfected mouse. Splenic gammadelta T cells from J(H)-/- mice with chronic malaria expressed Vgamma1+ or Vdelta4+ in the same ratio as uninfected controls with Vgamma1 cells dominating, but the Vgamma2 ratio declined about twofold. Gammadelta T cells from G8 mice specific for the TL antigen increased only 2-fold in number, compared with 10-fold in BALB/c controls, but G8 gammadelta T cells failed to express the B220 activation marker. Elimination of the parasite by drug treatment caused a slow depletion in the number of splenic gammadelta, CD4+, and CD8+ T cells. Following challenge, drug-cured J(H)-/- mice exhibited nearly identical parasitemia time courses as naïve controls. Depletion of either CD4+ T cells or gammadelta T cells from chronically infected J(H)-/- mice by monoclonal antibody treatment resulted in an immediate and significant (P < 0.05) exacerbation of parasitemia coupled with a marked decrease in splenic gammadelta T-cell numbers. The number of CD4+ T cells, in co...Continue Reading

References

Jan 1, 1979·The American Journal of Tropical Medicine and Hygiene·D W Roberts, W P Weidanz
Aug 1, 1990·Immunology Letters·M HoW P Weidanz
Jul 1, 1990·The Journal of Infectious Diseases·C RoussilhonA Bensussan
Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·B A HouldenJ A Bluestone
Sep 1, 1983·Infection and Immunity·J L Grun, W P Weidanz
Aug 1, 1995·Parasite Immunology·M R GoodierJ Langhorne
Jun 1, 1994·Current Opinion in Immunology·A O'Garra, K Murphy
Jun 25, 1993·Science·A W Taylor-RobinsonF Y Liew
Jan 1, 1994·The Journal of Experimental Medicine·M K PereraK N Mendis
Apr 1, 1993·The Journal of Experimental Medicine·F B WellsL A Matis
Aug 1, 1996·Journal of Leukocyte Biology·H C van der HeydeW P Weidanz
Feb 1, 1997·Experimental Parasitology·H C van der HeydeW P Weidanz
Jul 14, 2001·Science·R M Zinkernagel, H Hengartner
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y KatoN Minato
Mar 20, 2002·Current Molecular Medicine·F DieliA Salerno
May 30, 2002·Nature Reviews. Immunology·Simon R Carding, Paul J Egan
May 22, 2003·Microbes and Infection·Zheng W Chen, Norman L Letvin
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Dieter KabelitzMargot Zöller

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Citations

Jan 11, 2011·Nature Medicine·Michael F Good, Christian Engwerda
Jul 28, 2010·Infection and Immunity·William P WeidanzHenri C van der Heyde
Aug 13, 2009·European Journal of Immunology·Michelle N Wykes, Michael F Good
Jul 23, 2014·European Journal of Immunology·Miranda S OakleySanjai Kumar
Jul 4, 2012·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Jeannette HübenerHuu Phuc Nguyen
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan DoddPeter J M Openshaw

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