PMID: 8945101Nov 1, 1996Paper

Splenic irradiation in the palliation of patients with lymphoproliferative and myeloproliferative disorders

The American Journal of Hospice & Palliative Care
A C Paulino, S P Reddy

Abstract

Splenic irradiation is an accepted mode of treatment for palliation of hypersplenism and splenic pain for patients with lymphoproliferative or myeloproliferative disorders. However, results are conflicting regarding the duration of palliation and the toxicity associated with this treatment. Twenty-five patients with lymphoproliferative or myeloproliferative disorders were treated with splenic irradiation for palliation of splenomegaly and pain. The spleen was measured and pain and toxicity were assessed during radiation therapy. Splenomegaly and splenic pain decreased in 60 percent and 91 percent of patients, respectively. Radiation doses higher than 500 cGy appeared to be more effective than lower doses in reducing the spleen size in patients with chronic lymphocytic leukemia. Regression of splenomegaly and pain relief were maintained for less than one year and more than six months, respectively. Acute radiation toxicity resulted in the cessation of radiotherapy in two patients. Splenic irradiation is effective in the short-term palliation of splenomegaly and pain and may be most useful in the subset of patients with a life expectancy of less than one year. Terminally ill patients with splenomegaly secondary to lymphoprolifera...Continue Reading

References

Jan 1, 1989·International Journal of Radiation Oncology, Biology, Physics·M J GuineyI A Cooper
Jan 1, 1969·Clinical Radiology·F Ellis

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Citations

May 20, 2005·Clinical Oncology : a Journal of the Royal College of Radiologists·R Jyothirmayi, S Coltart
Mar 7, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M WeinmannM Bamberg
Aug 19, 2011·Leukemia & Lymphoma·Konstantin LavrenkovSamuel Ariad
Mar 3, 2007·Cancer·Stephen T LutzAndre A Konski
May 15, 2008·Journal of Medical Imaging and Radiation Oncology·R K ShrimaliN O'Rourke
Oct 5, 2010·The Cancer Journal·Stephen LutzBenjamin Corn
Sep 22, 2011·Current Protocols in Pharmacology·Matthew M SeaveyKristine L Stump
Mar 12, 2020·Case Reports in Surgery·David J HallChristiana M Shaw
Mar 18, 2021·OncoTargets and Therapy·Qiuying LiuLeslie A Andritsos
Apr 26, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·L PlacidiL Indovina

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