Splenic pathology after traumatic injury

American Journal of Clinical Pathology
D C Farhi, R Ashfaq

Abstract

Little is known concerning the pathology of spleens removed for traumatic injury. The authors studied the gross and microscopic features of 44 spleens removed for trauma and received at the Surgical Pathology Division of Parkland Memorial Hospital and 10 normal control spleens from the Medical Examiner's Office, Dallas County, Texas. The mean age of patients undergoing post-traumatic splenectomy was 29.6 years with a male:female ratio of 6:1. The most common procedure done for traumatic splenic rupture was splenectomy (39 of 44 cases); wedge resection or partial splenectomy was done in 5 cases. The mean weight of the spleens was 167 g (181 g in males, 93 g in females, P = .056). Capsular laceration or rupture were noted in 86% of post-trauma spleens, usually involving the superior pole and/or hilum. Subcapsular neutrophilic infiltrates were seen in 7%. Gross evidence of parenchymal hemorrhage was seen in 25%, and microscopic evidence in 68%. Control spleens showed none of these findings. Germinal centers were present in 77% of spleens with germinal center hyperplasia in 55% (including patients 16-59 years old), numerous primary follicles in 45%, mantle zone hyperplasia in 10%, and marginal zone hyperplasia in 41% of patient spl...Continue Reading

Citations

Feb 15, 2001·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·K Hansen, D B Singer
Aug 25, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dennis P O'MalleyAttilio Orazi
Apr 12, 2008·The Journal of Trauma·G Peter FakhreMatthew W Lube
Aug 12, 2009·Pathology Oncology Research : POR·Novica M MilićevićZivana Milićević
Feb 11, 2010·World Journal of Surgery·Ryan GertzDaniel R Margulies
Apr 17, 2008·Scandinavian Journal of Gastroenterology·Edgard WehbeDuane Osborne
Aug 30, 2003·Seminars in Diagnostic Pathology·Madeleine D Kraus

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