PMID: 7335378Oct 1, 1981Paper

Splenic phagocytic function in patients with inflammatory bowel disease

Pathology
D P JewellJ E Pettit

Abstract

Splenic phagocytic function has been assessed in patients with inflammatory bowel disease. No Howell-Jolly bodies were found on blood film examination. Slow clearance times of heat damaged red cells were found in 13 of 16 patients with ulcerative colitis compared with 4 of 17 patients with Crohn's disease (P less than 0.01). For ulcerative colitis prolonged clearance times were strongly related to the length of history (r = 0.90; P less than 0.01). The prolongation of half-clearance times correlated poorly with splenic size suggesting a functional impairment of the reticuloendothelial system.

References

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Oct 29, 1955·British Medical Journal·S C TRUELOVE, L J WITTS

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Citations

Jan 1, 1988·Irish Journal of Medical Science·B S RamehC F McCarthy
Feb 1, 1995·Gut·A F Muller, P J Toghill
Jan 1, 1987·Critical Reviews in Oncology/hematology·R H Sills
Jan 1, 1988·Acta Medica Scandinavica·L O PoulsenN Grunnet

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