Splenic rupture: a rare presentation of pancreatic carcinoma.

Archives of Pathology & Laboratory Medicine
Wendy M SmithWendy L Frankel

Abstract

Splenic rupture secondary to solid malignancy is an infrequent complication that usually occurs late in the progression of a previously diagnosed cancer. In rare instances, splenic rupture precipitates the discovery of an unsuspected pancreatic carcinoma. We report 2 cases of adenocarcinoma of the pancreas in which the patients presented with splenic rupture. To review the clinicopathologic features of splenic rupture due to pancreatic carcinoma and to increase awareness of malignancy as a possible etiology for atraumatic splenic rupture. We reviewed the clinical and pathologic data from 2 patients. A literature search was conducted to identify previous reports of splenic rupture associated with pancreatic cancer. We summarized the characteristics of the earlier cases and compared them with those of our patients. We found only 4 previous reports of splenic rupture preceding the diagnosis of pancreatic cancer. In 3 of these cases, the pancreatic carcinoma grossly invaded the spleen at the time of resection. In contrast, malignancy was not suspected as the etiology of the rupture in our patients until histologic examination of the resected spleen revealed carcinoma. Splenic rupture is an unusual presentation of cancer of the panc...Continue Reading

References

Apr 1, 1989·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·S ChungA K Li
Jul 1, 1989·Journal of Surgical Oncology·M R CanadyS L Strobel
Sep 30, 1999·Gastroenterology Clinics of North America·J S Barkin, J A Goldstein
Apr 4, 2000·Archives of Pathology & Laboratory Medicine·K Y Lam, V Tang
Jun 21, 2002·ANZ Journal of Surgery·Philip SmartGary Crosthwaite
Aug 10, 2002·European Journal of Gastroenterology & Hepatology·Pasha J NisarBrian J Rowlands
Aug 29, 2003·Journal of Clinical Pathology·F J HoarD Bareford
Sep 26, 2003·Pancreas·Euripides YettimisEmmanuel Kalokairinos

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Citations

Mar 22, 2007·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·William SterlacciAlexandar Tzankov
Sep 9, 2011·Journal of Medical Case Reports·Angelos KyriacouHaren Varia

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