Splenic small B-cell lymphoma with predominant red pulp involvement: a diffuse variant of splenic marginal zone lymphoma?

Histopathology
Manuela MollejoMiguel A Piris

Abstract

Splenic marginal zone lymphoma (SMZL) has been characterized by a micronodular pattern of infiltration, biphasic cytology, follicular replacement and the presence of marginal zone differentiation. Here we describe four cases with some distinctive features, such as diffuse splenic infiltration, lack of micronodules, marginal zone cytology, p53 inactivation and cutaneous involvement. In the course of a review of cases of SMZL, we recognized the existence of a subset of four cases of splenic B-cell lymphoma, with predominantly red pulp involvement, absence of follicular replacement, and a monomorphous population of tumoral cells resembling marginal zone B-cells, with scattered nucleolated blast cells. The immunophenotype (bcl2+, CD5-, CD10-, CD43-, CD23-, cyclin D1-, IgD- (3/4)) was consistent with SMZL. Bone marrow infiltration (4/4) and peripheral blood involvement (2/4) showed similar findings to those described for SMZL in these locations. However, unlike classical SMZL, 2/4 had cutaneous involvement, and 4/4 cases showed either p53 mutation or anomalous p53 staining (p53+, p21-). CONCLUSIONS; In spite of a diffuse pattern of splenic infiltration, cutaneous involvement and p53 alterations, these cases have findings that overla...Continue Reading

References

Apr 1, 1992·American Journal of Clinical Pathology·S T Traweek, K Sheibani
May 1, 1992·The American Journal of Surgical Pathology·C SchmidP G Isaacson
Oct 1, 1988·American Journal of Clinical Pathology·E AraiI Katayama
Mar 1, 1996·American Journal of Clinical Pathology·C D WuL J Medeiros
May 1, 1996·The American Journal of Surgical Pathology·R D HammerJ B Cousar
Jul 15, 1996·Blood·P G Isaacson

❮ Previous
Next ❯

Citations

Jun 10, 2009·Annals of Hematology·Jagdish AdiyodiRahuman Salim
Jan 25, 2008·Der Pathologe·M M Ott, H K Müller-Hermelink
Jan 25, 2008·Der Pathologe·A MarxT Rüdiger
Jan 4, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrew C Wotherspoon
Aug 29, 2012·Pathology International·Kei Shimizu-KohnoKoichi Ohshima
Apr 10, 2010·Haematologica·Luca Arcaini, Marco Paulli
Feb 8, 2003·The Lancet Oncology·Catherine ThieblemontBertrand Coiffier
Oct 1, 2014·Archives of Pathology & Laboratory Medicine·Amir Behdad, Nathanael G Bailey
Dec 3, 2013·Journal of Ultrasound·M CaremaniC Mazzarelli
May 10, 2007·Leukemia & Lymphoma·Shih-Sung ChuangElias Campo
Jul 16, 2011·American Journal of Clinical Pathology·Thierry J MolinaJames R Cook
Sep 3, 2011·Actas dermo-sifiliográficas·E Gómez-de la FuenteJ L López-Estebaranz
Aug 17, 2011·Seminars in Diagnostic Pathology·Miguel A PirisManuela Mollejo
Dec 1, 2010·Surgical Pathology Clinics·James R Cook
Dec 17, 2009·Human Pathology·Scott D DufresneSteven H Swerdlow
Oct 29, 2008·Hematology/oncology Clinics of North America·David J Good, Randy D Gascoyne
Sep 23, 2006·Hematology/oncology Clinics of North America·Robert W Sharpe, Kelly J Bethel
Nov 29, 2015·Best Practice & Research. Clinical Haematology·Andrew WotherspoonLarissa Sena Teixeira Mendes
Nov 25, 2005·Hematological Oncology·Manuela MollejoMiguel A Piris
Nov 25, 2011·British Journal of Haematology·Gail JonesUNKNOWN British Committee for Standards in Haematology
Dec 2, 2004·Blood Reviews·David OscierStephen Johnson
Jan 24, 2006·Human Pathology·Lorinda A SomaSteven H Swerdlow
May 2, 2016·Clinical Lymphoma, Myeloma & Leukemia·Hunan L JulhakyanV G Savchenko
Sep 13, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Fatima HamadehJames R Cook
Jun 28, 2016·Leukemia & Lymphoma·Alexandra Traverse-GlehenGilles Salles
Feb 8, 2011·Revista española de geriatría y gerontología·Carmen Eliana Peralta VargasJavier Pérez Alvarez
Dec 23, 2016·Journal of Cutaneous Pathology·Can BaykalNesimi Büyükbabani
Nov 26, 2002·Blood·Vito FrancoEmilio Iannitto
Apr 14, 2016·Terapevticheskiĭ arkhiv·L S Al-RadiV G Savchenko
Sep 2, 2016·São Paulo Medical Journal = Revista Paulista De Medicina·Mariana Nassif KerbauyJuliana Pereira
Jan 30, 2018·Journal of Cutaneous Pathology·Amin A HedayatRobert E LeBlanc
Aug 31, 2011·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Thomas BenterUlf Teichgräber
Aug 26, 2020·Seminars in Diagnostic Pathology·Julia T GeyerAttilio Orazi

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.