PMID: 6965606Feb 15, 1980Paper

Splenic T and B lymphocytes and their mitogenic response in untreated Hodgkin's disease

Cancer
T HanU Kim

Abstract

The splenic T and B cell distribution in 79 patients with untreated Hodgkin's disease was quite similar to that in 15 control patients with non-Hodgkin's lymphoma or carcinoma. The mean T lymphocyte percentage was slightly higher in involved spleens than in uninvolved spleens of patients with Hodgkin's disease. There was no significant difference in the T and B cell distribution between tumor area and tumor-free area of the same spleens of Hodgkin's disease patients. Splenic T and B cell distribution did not correlate well with the clinical features of Hodgkin's disease. The splenic T cell percentage was significantly lower than that of the peripheral blood T cell percentage (P less than 0.05), while the splenic B cell percentage was significantly higher than peripheral blood B cell percentage (P less than 0.01) in 13 patients with untreated Hodgkin's disease. The splenic T lymphocyte response to PHA was significantly higher than the peripheral blood T lymphocyte response (P less than 0.05), and the splenic B lymphocyte response to PHA, in the presence of irradiated autologous splenic T lymphocytes, was also significantly higher than the peripheral blood B lymphocyte response (P less than 0.05) in 8 and 6 patients with untreate...Continue Reading

References

Nov 3, 1977·The New England Journal of Medicine·J S GoodwinR C Williams
Jan 1, 1976·Journal of Immunological Methods·T Han, J Minowada
Dec 1, 1973·The Journal of Clinical Investigation·K J Gajl-PeczalskaR A Good
Jan 24, 1974·The New England Journal of Medicine·R Levy, H S Kaplan
Jan 1, 1972·Scandinavian Journal of Immunology·S S Fröland
Aug 1, 1973·The Journal of Clinical Investigation·K M MatchettW B Kremer
Oct 11, 1973·The New England Journal of Medicine·R L LongmireC G Craddock
Jan 1, 1974·Scandinavian Journal of Haematology·E Andersen
Jun 1, 1970·The American Journal of Medicine·T Han, J E Sokal
Nov 4, 1965·The New England Journal of Medicine·E M Hersh, J J Oppenheim
Sep 16, 1967·British Medical Journal·S D LawlerB R Reeves
Nov 1, 1962·The Journal of Clinical Investigation·A C AISENBERG

❮ Previous
Next ❯

Citations

May 1, 1994·Digestive Diseases and Sciences·C W WuS R Wang
Mar 1, 1988·The Japanese Journal of Surgery·T AkiyoshiH Tsuji
Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·D R Howard
Oct 1, 1987·American Journal of Hematology·A Janowska-WieczorekL M Pilarski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.