Splenic volume differentiates complicated and non-complicated celiac disease

United European Gastroenterology Journal
Tom van GilsChris J J Mulder

Abstract

Studies in small groups of patients indicated that splenic volume (SV) may be decreased in patients with celiac disease (CD), refractory CD (RCD) type II and enteropathy-associated T-cell lymphoma (EATL). The objective of this article is to evaluate SV in a large cohort of uncomplicated CD, RCD II and EATL patients and healthy controls. The retrospective cohort consisted of 77 uncomplicated CD (of whom 39 in remission), 29 RCD II, 24 EATL and 12 patients with both RCD II and EATL. The control group included 149 healthy living kidney donors. SV was determined on computed tomography. The median SV in the uncomplicated CD group was significantly larger than in controls (202 cm(3) (interquartile range (IQR): 154-275) versus 183 cm(3) (IQR: 140-232), p = 0.02). After correction for body surface area, age and gender, the ratio of SV in uncomplicated CD versus controls was 1.28 (95% confidence interval: 1.20-1.36; p < 0.001). The median SV in RCD II patients (118 cm(3) (IQR 83-181)) was smaller than the median SV in the control group (p < 0.001). This study demonstrates large inter-individual variation in SV. SV is enlarged in uncomplicated CD. The small SV in RCD II may be of clinical relevance considering the immune-compromised stat...Continue Reading

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Citations

Jul 18, 2019·Medicina·Daniel Vasile BalabanMariana Jinga
Mar 19, 2020·Current Gastroenterology Reports·Isabel A Hujoel, Joseph A Murray
Sep 9, 2019·The Lancet. Gastroenterology & Hepatology·Christophe CellierUNKNOWN RCD-II Study Group Investigators

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