Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice

Oncotarget
Fei WangChunmin Liang

Abstract

Immunosenescence contributes to pathogenesis of Alzheimer's disease (AD) in the elderly. In this study, we explored the effects of young wild type (WT) splenocytes (ySCs) on Alzheimer's disease by transplanting ySCs into APPswe/PSENldE9 transgenic mice. Young WT splenocytes not only prevented AD, but also improved the spatial learning and memory of APPswe/PSENldE9 transgenic mice. Young WT splenocytes enhanced Aβ clearance, decreased astrogliosis and increased systemic growth differentiation factor 11 (GDF11) levels. Splenocytes derived from old AD mouse promoted AD. There was an increased number of regulatory T cells (Tregs) among old AD splenocytes. We suggest that alterations of GDF11 and Tregs are involved in AD progression and that rejuvenation of the immune system is a potential therapeutic strategy in AD.

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Citations

Nov 2, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Howard E Gendelman, R Lee Mosley
May 11, 2017·Journal of Neuroscience Research·Samuel S DuffyGila Moalem-Taylor
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Mar 8, 2018·Immunology·Jodie StephensonSandra Amor
Feb 8, 2019·GeroScience·Marissa J Schafer, Nathan K LeBrasseur
Apr 28, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Tao MengHuawei Duan

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Methods Mentioned

BETA
transgenic
flow cytometry
flow
ELISA

Software Mentioned

SPSS19
Image [UNK]
NIH image J
NIH image J system
NIH image

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