PMID: 9523550Apr 2, 1998Paper

Splicing of a regulated exon reveals additional complexity in the axonal microtubule-associated protein tau

Journal of Neurochemistry
M L Wei, Athena Andreadis

Abstract

Tau is a microtubule-associated protein whose transcript undergoes complex regulated splicing in the mammalian nervous system. Exon 6 of the gene is an alternatively spliced cassette whose expression pattern and splicing regulation had not been previously analyzed in the human. The expression profile of exon 6 is completely different from that of the better-analyzed exons 2, 3, 4A, and 10, implying the utilization of distinct regulatory factors. The default splicing behavior of the exon had demonstrated the existence of what were initially considered cryptic splice sites. However, analysis of the expression pattern of exon 6 suggests that these splice sites are utilized in certain human tissues and, if translated, would result in a radically altered tau protein. Lastly, expression of exon 6 minigene constructs in cells indicates that its flanking exons are involved in its inclusion and in the modulation of the ratio of its variants.

Citations

Jul 25, 2006·Journal of Neuroscience Research·Olivier LeroyMarie-Laure Caillet-Boudin
Jan 26, 2000·Journal of Neurochemistry·Q S GaoA Andreadis
Jun 17, 2016·Journal of Neurochemistry·Liviu-Gabriel BodeaJürgen Götz
Mar 23, 2004·Journal of Cellular Biochemistry·Min-Hua LuoAthena Andreadis
Aug 5, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Susanne Froelich FabreLars Lannfelt
Sep 2, 2011·Journal of Molecular Neuroscience : MN·Payal RayJane Y Wu
Sep 15, 2004·Human Mutation·R RademakersC van Broeckhoven
Nov 11, 2010·Molecular Cancer Therapeutics·Tatiana SpicakovaBranimir I Sikic
Aug 14, 2020·International Journal of Biological Macromolecules·Shibi MuralidarBalamurugan Palaniappan
May 15, 2002·Brain Research. Molecular Brain Research·Meltem Cevik ArikanAthena Andreadis
Dec 11, 1999·Brain Research. Brain Research Protocols·O StossS Stamm
Dec 24, 2004·Biochimica Et Biophysica Acta·Nicolas SergeantLuc Buée
Jan 4, 2005·Biochimica Et Biophysica Acta·Lei GaoAthena Andreadis
Feb 21, 2006·Biochimica Et Biophysica Acta·Olivier LeroyMarie-Laure Caillet-Boudin
Aug 16, 2006·Journal of Molecular Biology·Patrick Barré, David Eliezer
Nov 19, 2009·Biochemistry·Nichole E LapointeLester I Binder
May 11, 2011·Neuron·Meaghan MorrisLennart Mucke

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