Splicing the Clock to Maintain and Entrain Circadian Rhythms.

Journal of Biological Rhythms
Iryna Shakhmantsir, Amita Sehgal

Abstract

Circadian clocks drive daily rhythms of physiology and behavior in multiple organisms and synchronize these rhythms to environmental cycles of light and temperature. The basic mechanism of the clock consists of a transcription-translation feedback loop, in which key clock proteins negatively regulate their own transcription. Although much of the focus with respect to clock mechanisms has been on the regulation of transcription and on the stability and activity of clock proteins, it is clear that other regulatory processes also have to be involved to explain aspects of clock function. Here, we review the role of alternative splicing in circadian clocks. Starting with a discussion of the Drosophila clock and then extending to other major circadian model systems, we describe how the control of alternative splicing enables organisms to maintain their circadian clocks as well as to respond to environmental inputs, in particular to temperature changes.

References

Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·I EderyM Rosbash
Jul 27, 1999·Science·M F CerianiS A Kay
Nov 26, 2002·Nature·Jui-Ming LinRavi Allada
Feb 4, 2003·Nature Neuroscience·Bikem AktenF Rob Jackson
Jun 28, 2003·Journal of Biological Rhythms·Yi Liu
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·B H CollinsC P Kyriacou
Sep 24, 2004·RNA·Alberto R KornblihttGuadalupe Nogues
Nov 10, 2004·Journal of Biological Rhythms·Jay C Dunlap, Jennifer J Loros
Aug 19, 2005·Genes & Development·Axel C R DiernfellnerMichael Brunner
Oct 1, 2005·Molecular Biology of the Cell·Hildur V ColotJay C Dunlap
Oct 1, 1954·Proceedings of the National Academy of Sciences of the United States of America·C S Pittendrigh
Aug 1, 2008·PLoS Biology·Saul KivimäeMichael W Young
Nov 4, 2008·Nature·Eric T WangChristopher B Burge
Feb 26, 2009·Cell·Markus C WahlReinhard Lührmann
Mar 20, 2009·PLoS Biology·Michael Rosbash
Oct 28, 2009·Genome Research·Sergei A FilichkinTodd C Mockler
Jan 19, 2011·Journal of Cell Science·Shihoko KojimaCarla B Green
May 10, 2011·Current Biology : CB·Laura B Duvall, Paul H Taghert
Jun 23, 2012·Genome Biology·Nicholas J McGlincyJernej Ule
Jul 4, 2012·Trends in Neurosciences·Xiangzhong Zheng, Amita Sehgal

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