PMID: 1201530Nov 1, 1975Paper

Split-brain rat: transfer and interference of kindled amygdala convulsions

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
D C McIntyre

Abstract

Rats were subjected to varying degrees of commissurotomy, followed by implantation of a bipolar electrode into each amygdala. After the kindling of six convulsions at one electrode (primary site), the procedure was applied to the contralateral amygdala (secondary site). Convulsions were observed to develop more rapidly, independent of the degree or kind of transection. After 6 secondary site convulsions, the primary site was re-tested and convulsion-triggering was blocked, except in animals with transection of the rostral portion of the corpus callosum (CC). Collectively, the data indicate: (i) amygdala kindling develops a lasting trace which operates through the midbrain or brainstem; (ii) kindling from a second site utilizes this trace; (iii) a series of 6 convulsions produces negative after-effect which manifests itself at the convulsion level via the anterior CC; (iv) the anterior CC is important in determining the laterality of the forelimb clonus; and (v) the inter-amygdala propagation of after-discharge is blocked by the combined sectioning of the anterior CC and the anterior commissure.

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R RacineS Chipashvili
Nov 1, 1973·Electroencephalography and Clinical Neurophysiology·D C McIntyre, G V Goddard
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Sep 1, 1959·Journal of Neurophysiology·R POBLETEA E WALKER

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Citations

Nov 1, 1975·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M E CorcoranJ A Wada
May 1, 1978·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J N Nobrega, J Gaito
Apr 18, 2002·Brain Pathology·Douglas A CoulterWolfgang Löscher
Jan 1, 1996·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·M N ShouseM Sammaritano
Jul 27, 2000·Annals of the New York Academy of Sciences·D C McIntyre, M E Kelly
Nov 1, 1975·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·W M Burnham
May 28, 2008·Epilepsia·Dan C McIntyre, Krista L Gilby
Feb 1, 1978·Epilepsia·J A McCaughranJ A Wada
Oct 1, 1982·Epilepsia·J A WadaY Kaneko
Feb 14, 2007·Epilepsia·Hal BlumenfeldHitten P Zaveri

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