PMID: 2502508Aug 1, 1989Paper

Split-course versus continuous-course irradiation in the postoperative setting for squamous cell carcinoma of the head and neck

International Journal of Radiation Oncology, Biology, Physics
R J AmdurN J Cassisi

Abstract

There is very little published information comparing split-course and continuous-course irradiation in the adjuvant setting. To evaluate this issue, a retrospective analysis was performed of 161 patients with squamous cell carcinoma of the head and neck who received split-course (27 patients) or continuous-course (134 patients) irradiation following radical surgical resection. At 5 years, the actuarial rate of disease control above the clavicles for continuous-course irradiation was 80% versus 44% for split course (p = .002). Stratification of patients by primary site, surgical margin, AJCC stage, and tumor dose revealed a statistically significant (p less than or equal to .05) advantage in most of the subgroups for patients treated with continuous-course irradiation. The overall and cause-specific survival rates were also much better for patients treated with continuous-course irradiation, and the difference was highly statistically significant (overall 5-year survival, continuous course, 33%; split course, 15% [p = .005]; cause-specific 5-year survival, continuous course, 57%; split course, 37% [p less than .001]). A stepwise multivariate analysis confirmed that the type of irradiation course (continuous vs. split) was an ind...Continue Reading

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