PMID: 6406397Apr 1, 1983Paper

Split-course versus continuous pelvis irradiation in carcinoma of the uterine cervix: a prospective randomized clinical trial of the Radiation Therapy Oncology Group

International Journal of Radiation Oncology, Biology, Physics
V A MarcialJ A Hanley

Abstract

In August 1980, the Radiation Therapy Oncology Group (RTOG) completed a prospective randomized clinical trial for the comparison of a split-course versus a standard continuous course of pelvic irradiation for carcinoma of the uterine cervix Stages II-B, III-A, III-B, and IV-A. The split-course consisted of 10 fractions of 250 rad each, 5 times a week, up to 2500 rad followed by a rest period of approximately 2 weeks and then another 2500 rad was given (250 X 10). The continuous course consisted of 30 fractions of 170 rad each, 5 times per week, for a total of 5100 rad. In both groups the external pelvis irradiation was followed by intracavitary brachytherapy in the uterus and vagina, with tandem-colpostat or tandem only, for a dose of 3000 rad at point A for the former, or at 2 cm from the center of the linear source for the latter. In cases where brachytherapy was not possible, a boost of external irradiation with reduced field, with a dose of 1600 rad (200 X 8) was advised. Three hundred and one patients were registered, of which 287 are currently evaluable. No differences between the treatments were detected for the following study end-points: treatment tolerance in terms of acute normal tissue reactions and completion of th...Continue Reading

References

Jun 1, 1972·Cancer·V A Marcial

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Citations

Jul 30, 1995·International Journal of Radiation Oncology, Biology, Physics·C A PerezM A Lockett
Apr 29, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N Tubiana-MathieuL Piana
Feb 8, 2003·International Journal of Radiation Oncology, Biology, Physics·Robson FerrignoWladimir Nadalin
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P. W. Grigsby
Sep 1, 1991·International Journal of Radiation Oncology, Biology, Physics·J J KovalicM A Lockett
Feb 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K SkladowskiG G Steel
Jul 2, 2005·International Journal of Radiation Oncology, Biology, Physics·Robson FerrignoJoão Victor Salvajoli
Sep 28, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Francisco José Andreu-Martínez, Julia M Martínez-Mateu
Jun 28, 2006·Behavioral and Cognitive Neuroscience Reviews·D Erik EverhartAmy J Shipley
Nov 26, 2013·The Cochrane Database of Systematic Reviews·Henry J McQuaySheena Derry

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