Abstract
Objective: Split-hand sign is a useful clinical and electrophysiological feature in the diagnosis of amyotrophic lateral sclerosis (ALS). We proposed a novel split-hand index (SI) using F-wave persistence (FP) and assessed its diagnostic utility in ALS. Methods: Eighty-three consecutive ALS patients were recruited, and 50 healthy, age-, and height-matched volunteers were used as a control group. Compound muscle action potentials (CMAP) and FP were recorded from the abductor pollicis brevis (APB), first dorsal interosseous (FDI), and the abductor digiti minimi (ADM) muscles. The SI derived from FP was calculated using the following formula: SIFP = (FPAPB ×FPFDI)/FPADM. The sensitivity and specificity of SIFP and SICMAP in differentiating ALS from healthy controls (HCs) were derived from receiver-operating characteristic (ROC) curve analysis. Results: Both SIFP and SICMAP were significantly reduced in ALS patients. The ROC curve analysis indicated that both SIFP and SICMAP reliably differentiated ALS from HCs [0.92 (95% CI: 0.88-0.95); 0.86 (95% CI: 0.82-0.91)], but SIFP showed better diagnostic accuracy than SICMAP (p = 0.04), with a high sensitivity (81.2%) and specificity (97%). In subgroup analyses, SIFP appeared to be a bett...Continue Reading
References
Jul 9, 1999·Muscle & Nerve·S KuwabaraT Hattori
Aug 24, 1999·Muscle & Nerve·J A NobregaP T Monteagudo
Dec 14, 1999·Journal of the Neurological Sciences·J M CedarbaumA Nakanishi
Nov 25, 2000·Journal of the Neurological Sciences·M WeberN Hirota
Aug 3, 2002·Neurologic Clinics·Morris A Fisher
Dec 24, 2002·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·Mamede de CarvalhoMichael Swash
May 9, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Andreas A ArgyriouElisabeth Chroni
Nov 23, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·N C VoermansM J Zwarts
Feb 1, 2008·Muscle & Nerve·Satoshi KuwabaraUNKNOWN Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group
Jul 1, 2010·Muscle & Nerve·Christoph NeuwirthMarkus Weber
Feb 8, 2011·Lancet·Matthew C KiernanMargaret C Zoing
Nov 22, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Andrew Eisen, Satoshi Kuwabara
Jul 17, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hua PanJun Kimura
Sep 29, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Parvathi MenonSteve Vucic
Oct 27, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark B Bromberg
Jul 23, 2013·Muscle & Nerve·Aude-Marie GrapperonShahram Attarian
Jan 30, 2014·PloS One·Parvathi MenonSteve Vucic
Aug 27, 2014·Muscle & Nerve·Akiko HachisukaKenji Hachisuka
Oct 29, 2015·Muscle & Nerve·Dong-Gun KimJung-Joon Sung
Jun 5, 2018·Animal : an International Journal of Animal Bioscience·Y Z ShenM Z Wang
Citations
Jul 2, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Zhi-Li WangLiying Cui
Sep 26, 2020·Scientific Reports·Young Gi MinJung-Joon Sung
Jul 20, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nan HuMingsheng Liu
Oct 29, 2021·Brain and Behavior·Andrew Eisen, Peter Bede