Split-hand index in amyotrophic lateral sclerosis: an F-wave study

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Zhi-Li WangLi-Ying Cui

Abstract

Objective: Split-hand sign is a useful clinical and electrophysiological feature in the diagnosis of amyotrophic lateral sclerosis (ALS). We proposed a novel split-hand index (SI) using F-wave persistence (FP) and assessed its diagnostic utility in ALS. Methods: Eighty-three consecutive ALS patients were recruited, and 50 healthy, age-, and height-matched volunteers were used as a control group. Compound muscle action potentials (CMAP) and FP were recorded from the abductor pollicis brevis (APB), first dorsal interosseous (FDI), and the abductor digiti minimi (ADM) muscles. The SI derived from FP was calculated using the following formula: SIFP = (FPAPB ×FPFDI)/FPADM. The sensitivity and specificity of SIFP and SICMAP in differentiating ALS from healthy controls (HCs) were derived from receiver-operating characteristic (ROC) curve analysis. Results: Both SIFP and SICMAP were significantly reduced in ALS patients. The ROC curve analysis indicated that both SIFP and SICMAP reliably differentiated ALS from HCs [0.92 (95% CI: 0.88-0.95); 0.86 (95% CI: 0.82-0.91)], but SIFP showed better diagnostic accuracy than SICMAP (p = 0.04), with a high sensitivity (81.2%) and specificity (97%). In subgroup analyses, SIFP appeared to be a bett...Continue Reading

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Citations

Jul 2, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Zhi-Li WangLiying Cui
Jul 20, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nan HuMingsheng Liu

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