Splitting a droplet for femtoliter liquid patterns and single cell isolation

ACS Applied Materials & Interfaces
Huizeng LiYanlin Song

Abstract

Well-defined microdroplet generation has attracted great interest, which is important for the high-resolution patterning and matrix distribution for chemical reactions and biological assays. By sliding a droplet on a patterned superhydrophilic/superhydrophobic substrate, tiny microdroplet arrays low to femtoliter were achieved with uniform volume and composition. Using this method, cells were successfully isolated, resulting in a single cell array. The droplet-splitting method is facile, sample-effective, and low-cost, which will be of great potential for the development of microdroplet arrays for biological analysis as well as patterning system and devices.

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Citations

Feb 6, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Ziyang LuXuehua Zhang
Dec 8, 2015·ACS Applied Materials & Interfaces·Jiazhen SunYanlin Song
Mar 5, 2016·The Journal of Physical Chemistry Letters·Lei BaoXuehua Zhang
Jul 21, 2015·Small·Lei WuYanlin Song
Jul 15, 2015·Small·Lei BaoXuehua Zhang
Feb 27, 2016·Advanced Materials·Wenqian FengPavel A Levkin
May 18, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Shuhua PengXuehua Zhang
Aug 9, 2016·ACS Applied Materials & Interfaces·Haitao YuXuehua Zhang
Aug 16, 2016·Nature Communications·Yanzhen ZhangGunther Wittstock
Oct 22, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Ziyang LuXuehua Zhang
Nov 2, 2016·Nanoscale·Wanxin ShiShutao Wang
Jan 13, 2017·The Journal of Physical Chemistry Letters·Shuhua PengXuehua Zhang
Mar 28, 2017·Lab on a Chip·Haitao YuXuehua Zhang
Feb 19, 2016·Materials·Sera ShinTaeyoon Lee
Mar 7, 2019·Nature Communications·Huizeng LiYanlin Song
Aug 14, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuemeng YangShutao Wang
Mar 10, 2017·The European Physical Journal. E, Soft Matter·Brendan DyettXuehua Zhang
Jan 25, 2018·Physical Chemistry Chemical Physics : PCCP·Lei LeiXuehua Zhang
Mar 25, 2018·Advanced Materials·Wenqian FengPavel A Levkin
Jan 20, 2021·ACS Biomaterials Science & Engineering·Vittorio FerraraBruno Pignataro
Nov 8, 2017·ACS Applied Materials & Interfaces·Qiang YangYanlin Song
Nov 10, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Xiaolong YangVictor Breedveld
Jul 20, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Brendan DyettXuehua Zhang
Dec 28, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Lei WuYanlin Song
Oct 20, 2018·ACS Applied Materials & Interfaces·Junjie ChiZhongze Gu
Nov 19, 2021·Physical Chemistry Chemical Physics : PCCP·Dongliang LiQiang Liao

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