SPOC: a widely distributed domain associated with cancer, apoptosis and transcription

BMC Bioinformatics
Luis Sánchez-PulidoAlfonso Valencia

Abstract

The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level. We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches and structural prediction methods. The widely distributed DIO (Death inducer-obliterator) family is related to cancer and apoptosis and offers new clues about SPOC domain functionality.

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Citations

May 9, 2007·Cell Research·Shi-Yan ChenXiu-Ling Cai
Mar 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Glen D RaffelD Gary Gilliland
Feb 27, 2008·Acta Pharmacologica Sinica·Yong WangQiu-ling Wu
Sep 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Dong Yan, Norbert Perrimon
Oct 7, 2016·Cell Division·Humberto Contreras-CornejoAlejandro Bravo-Patiño
Mar 24, 2017·Stem Cell Reports·Agnes FüttererCarlos Martinéz-A
Sep 8, 2017·Breast Cancer Research : BCR·Stéphanie LégaréMark Basik
Aug 30, 2017·Genetics and Molecular Biology·María Gloria Solís-GuzmánMiguel Martínez-Trujillo
Jul 10, 2020·Cell Death & Disease·Yang LiZhen Liu

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Methods Mentioned

BETA
GTPase

Software Mentioned

WHATIF
Coffee
BLAST
hmmsearch
PHD
HMMer
PSQS
FFAS

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