Spondyloarthropathy in inflammatory bowel disease patients on TNF inhibitors

Internal Medicine Journal
K SubramaniamP Pavli

Abstract

Musculoskeletal symptoms are the most common extra-intestinal manifestation associated with inflammatory bowel disease (IBD). Spondyloarthritis (SpA) is an umbrella term applied to a group of rheumatic diseases with some features in common and others distinct from other inflammatory arthritides. To determine self-reported prevalence of SpA associated musculoskeletal manifestations in an IBD cohort on tumour necrosis factor (TNF) inhibitors using a questionnaire incorporating Assessment of SpondyloArthritis International Society (ASAS) criteria. Consecutive IBD patients on TNF inhibitors attending a single IBD centre (May-September 2011) were asked to complete a SpA questionnaire. Data collected included SpA and IBD variables, demographics, concurrent medications, co-morbidities and autoimmune serology. The 140-patient cohort included 96 suffering from Crohn disease and 44 from ulcerative colitis. The mean age of disease onset was 29.3 years and 45% were men. Concurrent or past history of inflammatory back pain was reported by 29% subjects. Using the imaging and clinical arms of the ASAS criteria, 30% and 14% subjects respectively had axial SpA. Arthritis was reported by 34%, enthesitis 17%, dactylitis 4%, uveitis 6%, psoriasis ...Continue Reading

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Citations

Jan 25, 2017·Joint, Bone, Spine : Revue Du Rhumatisme·Maxime SondagDaniel Wendling
Sep 8, 2017·Expert Review of Clinical Pharmacology·Lieven PouillonLaurent Peyrin-Biroulet
Sep 25, 2019·Scandinavian Journal of Gastroenterology·Davide Giuseppe RibaldoneMarco Astegiano
May 25, 2020·Intestinal research·Akira HokamaJiro Fujita
Dec 12, 2020·Journal of the American Academy of Dermatology·Michael J MurphyWilliam Damsky

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