Sponges and Predators in the Small RNA World

Microbiology Spectrum
Nara Figueroa-Bossi, Lionello Bossi

Abstract

Most noncoding small RNAs (sRNAs) that regulate gene expression do so by base-pairing with mRNAs, affecting their translation and/or stability. Regulators as evolutionarily distant as the trans-encoded sRNAs of bacteria and the microRNAs (miRNAs) of higher eukaryotes share the property of targeting short sequence segments that occur in multiple copies in bacterial and eukaryotic transcriptomes. This target promiscuity has major implications for sRNA function. On the one hand, it allows the sRNA to coordinately control several different targets and thus be at the center of regulatory networks. On the other hand, it allows the existence of target mimics or decoys that divert the sRNA/miRNA away from bona fide targets and thus serve as mechanisms to regulate the regulator. In addition, by competing for pairing with the same sRNA, bona fide targets establish a cross talk that can impact on each other's expression levels. Here we review evidence that target mimicry and competition are important components of the regulatory architecture of bacterial sRNA networks.

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Citations

Jun 27, 2019·Annals of the New York Academy of Sciences·Ascensión Ariza-MateosJordi Gómez
Jan 27, 2019·Journal of Applied Genetics·Aleksandra KozińskaIzabela Sitkiewicz
Sep 24, 2021·Nucleic Acids Research·Kim Boi Le HuyenSvetlana Chabelskaya
Nov 30, 2021·ELife·Sarah Lauren Svensson, Cynthia Mira Sharma

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