Sponges (Porifera) model systems to study the shift from immortal to senescent somatic cells: the telomerase activity in somatic cells

Mechanisms of Ageing and Development
C KoziolW E Müller

Abstract

Sponges (Porifera) represent the lowest metazoan phylum, characterized by a pronounced plasticity in the determination of cell lineages. In a first approach to elucidate the molecular mechanisms controlling the switch from the cell lineage with a putative indefinite growth capacity to senescent, somatic cells, the activity of the telomerase as an indicator for immortality has been determined. The studies were performed with the marine demosponges Suberites domuncula and Geodia cydonium. It was found that the activity for the telomerase in the tissue of both sponges is high; a quantitative analysis revealed that the extract from S. domuncula contained 10.3 TPG units per 5000 cell equivalents and the one from G. cydonium 8.3 TPG units; hence the activity reached approximately 30-20% of the activity seen in telomerase-positive reference cells. In contrast, dissociated spherulous cells from G. cydonium, after an incubation period of 24 h, contained no detectable telomerase activity. From earlier studies it is known that isolated sponge cells do not proliferate. Based on these findings it is assumed that the separation of the senescent sponge cell lineage from the immortal germ/somatic cell lineage is triggered by the loss of contac...Continue Reading

References

Apr 29, 1991·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T B Kirkwood, M R Rose
Mar 1, 1991·Mutation Research·C B Harley
May 31, 1990·Nature·C B HarleyC W Greider
Aug 30, 1990·Nature·N D HastieR C Allshire
Jan 1, 1986·Experimental Gerontology·B L Strehler
Jan 1, 1994·Cold Spring Harbor Symposia on Quantitative Biology·C B HarleyC W Greider
Jul 28, 1995·Biochimica Et Biophysica Acta·P J Vojta, J C Barrett
Jul 1, 1995·Die Naturwissenschaften·W E Müller
Jan 1, 1995·Die Naturwissenschaften·W E MüllerV Gamulin
Jan 1, 1993·Cold Spring Harbor Symposia on Quantitative Biology·M S LeeE H Blackburn
Jan 1, 1993·Trends in Genetics : TIG·H Denis, J C Lacroix
Jun 1, 1996·Molecular and Cellular Biology·S E HoltJ W Shay
Oct 1, 1996·Journal of Molecular Evolution·M KruseW E Müller
Jan 1, 1997·The Journal of Investigative Dermatology·R D RamirezR S Taylor
May 30, 1997·The Journal of Biological Chemistry·M Mandal, R Kumar
Dec 1, 1995·Cell Biology International·G ImsieckeW E Müller
May 19, 2005·Progress in Molecular and Subcellular Biology·W E Müller
Mar 1, 1975·Wilhelm Roux's Archives of Developmental Biology·G Van de Vyver, Ph Willenz

❮ Previous
Next ❯

Citations

May 12, 2004·Marine Biotechnology·Gang-Hua LangMasatoshi Matsumura
Jan 12, 2011·Marine Biotechnology·Lubov I ChernogorAlexander V Ereskovsky
Nov 16, 2012·Marine Biotechnology·Francesca MussinoMarco Giovine
Mar 27, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Walther TrautJan Zrzavý
Nov 17, 2009·In Vitro Cellular & Developmental Biology. Animal·Marina PozzoliniMarco Giovine
Nov 19, 2003·Pathologie-biologie·A Macieira-Coelho
Nov 27, 1999·Mechanisms of Ageing and Development·E Richelle-Maurer, G Van de Vyver
Nov 9, 2002·Journal of Biotechnology·D SipkemaR H Wijffels
Oct 1, 2003·Biotechnology Advances·El Hassan BelarbiEmilio Molina Grima
Jun 26, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·W E Müller
Jul 27, 2010·FEBS Letters·Nuno M V GomesWoodring E Wright
Jan 30, 2004·Biotechnology and Bioengineering·Detmer SipkemaRené H Wijffels
Mar 2, 2005·Biotechnology and Bioengineering·Detmer SipkemaRené H Wijffels
Jan 28, 2003·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Sylvia BousmanJanis Shampay
Jul 25, 2000·Mechanisms of Development·H C SchröderW E Müller
Jun 30, 2006·Seminars in Cell & Developmental Biology·Werner E G Müller
Jan 11, 2018·Marine Drugs·Helena ĆetkovićMaja Herak Bosnar
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H C SchröderW E Müller
Apr 20, 2020·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Laurel S HiebertStefano Tiozzo
Sep 25, 1999·Molecular Reproduction and Development·S MuellerG Brem
Aug 18, 2012·The Journal of Experimental Biology·Camille Martinand-MariStephen Baghdiguian
Aug 12, 2003·The Journal of Experimental Biology·Matthias WiensWerner E G Müller
Nov 17, 2009·The Journal of Experimental Biology·J M De GoeijB Schutte
Aug 16, 2003·Biomolecular Engineering·Werner E G MüllerHeinz C Schröder
Jun 18, 2010·Ageing Research Reviews·David Neill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis