Spongian diterpenes with thyrotropin releasing hormone receptor 2 binding affinity from Spongia sp

Journal of Natural Products
Anthony R CarrollRonald J Quinn

Abstract

High-throughput screening of a plant and marine invertebrate extract library to find natural products with rat thyrotropin releasing hormorne (TRH) receptor 2 binding affinity led to the isolation of four new (1-4) and one known (5) spongian diterpene from the sponge Spongia sp. The structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. The absolute configurations of 1-4 were proposed on the basis of analysis of their CD spectra. Diterpenes 1-5 showed rat TRH receptor 2 binding affinity with IC(50) values of 23 microM, 70 microM, 400 microM, 600 microM, and 1 mM, respectively.

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R E StraubM C Gershengorn
May 1, 1983·British Journal of Pharmacology·G BoschiS Wrigglesworth
Sep 1, 1993·Molecular and Cellular Endocrinology·S M DuthieK A Eidne
Sep 15, 1998·Biochemical and Biophysical Research Communications·H ItadaniM Ohta
Mar 31, 2006·Natural Product Reports·Robert A KeyzersMichael T Davies-Coleman
Jun 15, 2007·Journal of Natural Products·Ludmila P PonomarenkoValentin A Stonik

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Citations

Jul 28, 2016·Marine Drugs·Patrícia MáximoAna Lourenço
Aug 21, 2009·Natural Product Reports·James R Hanson
Jan 30, 2010·Natural Product Reports·John W BluntMichèle R Prinsep
Aug 9, 2013·Natural Product Reports·Curtis J Henrich, John A Beutler
Apr 30, 2010·Journal of Natural Products·Anthony R CarrollRonald J Quinn
Apr 7, 2009·The Journal of Organic Chemistry·Leiv K SydnesMiriam Hanstein
Jul 6, 2014·Journal of Natural Products·Stephen M ParrishPhilip G Williams

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