Spontaneous adverse drug reaction monitoring in oncology: Our experience

Indian Journal of Cancer
Kirandeep KaurSandeep Kaushal

Abstract

Adverse drug reaction (ADR) monitoring is slowly developing as an important aspect of healthcare. The aim of the study was to study the pattern of adverse drug reactions in the Oncology department of a tertiary care hospital. This was a prospective study conducted in the Oncology department of a tertiary care hospital in which ADRs were reported spontaneously. The ADRs were noted from 1st January, 2007 to 30th June, 2011. Following were noted: demographics, premedication (if any), diagnosis, chemotherapy (regimen, cycles), medication history, and alteration in the treatment or co morbidities, ADRs (severity and management). Adverse drug reactions were noted by patient interview, collaborating with information on file, recording changes in the prescribing chart and investigations, consulting the doctor on duty. During this study period, there were total of 14,475 visits of patients from which 2500 ADRs were recorded. Maximum number of ADRs were noted with platinum compounds (25.52%) followed by pyrimidine antagonists (19.88%). The most common malignancy reported in our hospital was Carcinoma breast (20%) followed by leukemia (12%) and Ca ovary (12%). Alopecia (27.76%) was the most common ADR followed by anemia (7.48%), thrombocy...Continue Reading

References

May 13, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Lorna Hazell, Saad A W Shakir
May 18, 2007·British Journal of Clinical Pharmacology·Bharat T ThakrarLucette Doessegger
Jul 31, 2007·British Journal of Clinical Pharmacology·R ArulmaniB Suresh
Aug 13, 2009·BMC Clinical Pharmacology·Kazeem A Oshikoya, Jacob O Awobusuyi

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