Abstract
To describe ventilatory dynamics following the onset of ventricular fibrillation (VF) in an experimental swine model. Twelve female mixed-breed domestic swine (mean mass 21.3 +/- 1.7 kg) were sedated with IM ketamine (10 mg/kg) and xylazine (1 mg/kg), anesthetized with alpha-chloralose (40 mg/kg loading dose, 10 mg/kg/hr maintenance infusion), intubated, and mechanically ventilated on room air. ECG, and aortic and pulmonary artery pressures were monitored continuously. VF was induced with a 3-sec, 60-Hz, 100-mA transthoracic shock, and left untreated for 8 minutes. Respiratory rate, tidal volume, and minute ventilation were recorded until respiratory activity ceased. All 12 animals (100%) had agonal respirations through the first 2 minutes of arrest. This decreased to 11 (92%) at minute 3, five (42%) at minute 4, and two (17%) at minute 7. Mean respiratory rates ranged from 6 to 11 breaths/min. Mean tidal volumes ranged from 502 to 852 mL. Mean minute ventilations ranged from 3.3 to 5.8 L. In this swine model, 11 of 12 (92%) continued to have spontaneous agonal respirations for the first 3 minutes of VF cardiac arrest. Many animals had supranormal tidal volumes, and near-normal minute ventilations. These findings have potential...Continue Reading
References
Dec 1, 1992·Annals of Emergency Medicine·J J ClarkM S Eisenberg
Aug 1, 1991·Resuscitation
Feb 1, 1990·Annals of Emergency Medicine·J P OrnatoA G Rostafinski
Feb 1, 1990·Annals of Emergency Medicine·M S EisenbergT R Hearne
Jan 1, 1989·Resuscitation·A MullieR Van Hoeyweghen
Dec 1, 1994·Circulation·N C ChandraS Permutt
Aug 9, 1993·Archives of Internal Medicine·B E Brenner, J Kauffman
Citations
May 29, 2000·Resuscitation·K LurieP Sukhum
Aug 2, 2001·Resuscitation·V WenzelP J Baskett
Apr 12, 2003·Critical Care Medicine·Nemer SamniahKeith G Lurie
Nov 23, 2006·Critical Care Medicine·Mioara D Manole, Robert W Hickey
Mar 10, 2000·Pacing and Clinical Electrophysiology : PACE·C W CallawayJ J Menegazzi
Aug 3, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·H E WangM Hsieh
Feb 22, 2008·Journal of Veterinary Internal Medicine·S J Plunkett, M McMichael
Aug 10, 2010·BMC Cardiovascular Disorders·Mathias ZuercherKarl B Kern
Jul 26, 2006·Pediatric Research·Mioara D ManoleBradley B Keller
Dec 17, 2014·Annales de pathologie·Philippe CharlierLuc Brun
Jan 28, 1998·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·S C TadlerJ J Menegazzi
Oct 28, 2008·Resuscitation·Masaru SuzukiNaoki Aikawa
May 18, 2007·Resuscitation·Charles D DeakinTed Tabor
Sep 27, 2015·Resuscitation·Lianxing ZhaoYingying Fang
Aug 30, 2006·The American Journal of Emergency Medicine·Eric M Rottenberg
Jul 13, 2006·Resuscitation·Gavin D PerkinsKoenraad G Monsieurs
Dec 30, 2014·The American Journal of Emergency Medicine·Eric M Rottenberg
Jun 28, 2016·Internal and Emergency Medicine·Eric Marc Rottenberg
Aug 9, 2016·The American Journal of Emergency Medicine·Eric M Rottenberg
Jun 7, 2017·Resuscitation·Martha WolfskeilSaid Hachimi-Idrissi
Feb 16, 2018·Prehospital and Disaster Medicine·Eric M Rottenberg
Jun 2, 2005·Current Opinion in Critical Care·Thomas D Rea
May 16, 2015·Critical Care Medicine·Eric M Rottenberg
Mar 12, 2009·Current Opinion in Critical Care·Mathias Zuercher, Gordon A Ewy
May 22, 2010·Journal of Applied Physiology·Philippe HaouziKevin Gleeson
Nov 20, 2018·Yonsei Medical Journal·Yong Won KimKyoung Chul Cha
Jan 14, 2000·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·R A SworK H Chu
Aug 5, 2010·Critical Care Medicine·Shuo WangJunyuan Wu