PMID: 9437265Jan 23, 1998Paper

Spontaneous anaplastic large cell lymphoma in a chimpanzee: a clinicopathological and immunohistochemical study

Journal of Medical Primatology
A A BinhazimT A Rizvi

Abstract

An anaplastic large cell lymphoma with disseminated abdominal metastases was diagnosed in a 35-year-old male chimpanzee. Clinically, the animal displayed lethargy, weight loss, ascites, and abdominal distention. Imaging studies showed several large abdominal masses. At necropsy, variably sized masses of neoplastic mesenteric lymph nodes that encompassed several intestinal loops were present throughout the abdomen. The largest mass measured 9 x 5 cm and had cauliflower-like protrusions into the jejunal lumen. The entire abdominal cavity was covered by a sheet of neoplastic tissue. Histopathologically, the tumor consisted of solid sheets of proliferating lymphoid cells forming a cohesive growth that filled the lymph node sinuses. The tumor had invaded the intestinal wall. Anaplastic large cell lymphoma was diagnosed from immunohistochemistry findings on the basis of positive reaction to the CD3 and CD30 markers and negative reaction to the CD20 marker. Serologic analysis revealed positive titers for Epstein-Barr, cytomegalo-, and varicella-zoster viruses. Both serologic and virologic studies showed no evidence of detectable retroviral infection. This type of tumor has not been reported before in the chimpanzee.

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Citations

Oct 18, 2003·Experimental Animals·Masaki MichishitaKimimasa Takahashi
Apr 16, 2009·Journal of Medical Primatology·S L BrownG B Hubbard
Jan 31, 2015·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Offiong F IkpattCarolyn Cray
Apr 19, 2017·Journal of Medical Primatology·Hannah LaurenceEdward J Dick
Mar 1, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Katherine N Gibson-Corley, Joseph S Haynes
Oct 25, 2013·Journal of Toxicologic Pathology·Itaru YamaguchiKatsumi Takaba
May 26, 2017·Journal of Medical Primatology·Shyamesh KumarEdward J Dick
Oct 8, 2009·Alternatives to Laboratory Animals : ATLA·Jarrod Bailey

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