Spontaneous and cholecystokinin-octapeptide-promoted regeneration of the pancreas following L-arginine-induced pancreatitis in rat

International Journal of Pancreatology : Official Journal of the International Association of Pancreatology
Péter HegyiJános Lonovics

Abstract

In L-arginine (Arg)-induced pancreatitis, evidence of acute inflammation was observed on d 1-3. Continuous tissue atrophy became visible at the sites of previous pancreatic necrosis, with simultaneous regeneration of the pancreas, mainly around the Langerhans islets. Administration of low doses of cholecystokinin-octapeptide (CCK-8) increased the inflammatory signs of pancreatitis in the early phase, but subsequently diminished the level of atrophy and accelerated the processes of regeneration in this model of pancreatitis. The aim of this work was to study the regenerative processes following Arg-induced pancreatitis in rats. Besides the spontaneous regeneration, the effects of low doses of CCK-8 on the laboratory and morphologic parameters in this type of experimental pancreatitis were investigated. Male Wistar rats were divided into three groups. In group I, the rats received 200 mg/100 g body weight of Arg i.p. twice, at an interval of 1 h, and 0.5 mL saline was administered s.c. twice daily. In group II, besides the same amount of Arg, the rats received 1 microgram/kg of CCK-8 s.c. in 0.5-mL saline twice daily (7 AM and 7 PM). In the control animals (group III), an identical amount of glycine was administered i.p. instead ...Continue Reading

References

Jul 1, 1978·The Journal of Physiology·J C Dagorn
Mar 1, 1990·Digestive Diseases and Sciences·S TaniM Otsuki
Jul 1, 1989·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·I NagyV Varró
Dec 1, 1989·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·G Z LászikV Varró
Dec 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·M CeskaB Brown
Mar 1, 1984·The Journal of Nutrition·T MizunumaY Kishino
Apr 1, 1994·Experimental and Molecular Pathology·C WeaverJ M Polak
Dec 1, 1993·Scandinavian Journal of Gastroenterology·C P DelaneyJ M Fitzpatrick
Jan 1, 1953·Scandinavian Journal of Clinical and Laboratory Investigation·J GOA
Nov 1, 1961·Archives of Biochemistry and Biophysics·B F ERLANGERW COHEN
Jan 1, 1962·Clinica Chimica Acta; International Journal of Clinical Chemistry·A HYVARINEN, E A NIKKILA

❮ Previous
Next ❯

Citations

Dec 11, 2014·World Journal of Gastroenterology : WJG·Stephanie L M DasMaxim S Petrov
May 21, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·László CzakóMakoto Otsuki
Dec 5, 2009·European Journal of Pharmacology·Shabir SidhuK L Khanduja
Feb 26, 2010·Pancreas·Tetsuhide ItoUNKNOWN Research Committee of Intractable Diseases of the Pancreas
Apr 23, 2010·Fundamental & Clinical Pharmacology·Shabir SidhuK L Khanduja
Aug 20, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ana María GonzálezXavier Molero

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.