Spontaneous and evoked ectopic discharges recorded from single human axons

Muscle & Nerve
V G Macefield

Abstract

A quantitative assessment was made of the firing characteristics of repetitive axonal discharges encountered during microneurographic recordings from human peripheral nerves. Spontaneous activity was recorded from 16 single axons using tungsten microelectrodes inserted percutaneously into fascicles of the median or peroneal nerves in normal subjects. These discharges typically consisted of brief bursts of 2-5 spikes occurring at a frequency of 7-10 Hz. Peak instantaneous frequencies usually exceeded 300 Hz. Based on their similarity with spontaneous high-frequency discharges recorded from single axons following nerve damage, ischemia, prolonged electrical stimulation, or hyperventilation, it is concluded that they are generated ectopically at the site of a previous impalement of a nerve fiber. It is suggested that short-term damage to the nerve fiber caused by the microelectrode may allow accumulation of K+ underneath the myelin, triggering an inward flow of K+ and regenerative depolarizations. Alternatively, internodal channels may be exposed following damage to the myelin, resulting in the generation of spontaneous pacemaker potentials and repetitive discharges.

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Citations

Dec 18, 2001·The Journal of Physiology·P A McNulty, V G Macefield
Oct 5, 2011·The Journal of Physiology·Marco Alessandro MinettoDario Farina
Jun 9, 2009·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Juhani V PartanenJari P A Arokoski
Feb 19, 2000·Muscle & Nerve·I MogyorosD Burke
Oct 12, 2007·Physical Biology·Radhika MadhavanSteve M Potter
Dec 18, 2003·The Journal of Physiology·Yacov Fischer

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