PMID: 8955556Nov 1, 1996Paper

Spontaneous and gonadotropin-releasing hormone-stimulated cytosolic calcium rises in individual goldfish gonadotrophs

Cell Calcium
P Mollard, Olivier Kah

Abstract

The cytosolic free calcium concentration, [Ca2+]i, was monitored in single isolated goldfish gonadotrophs with the fluorescent probe Indo-1. It was found that goldfish gonadotrophs exhibit both spontaneous and secretagogue-induced [Ca2+]i rises. Spontaneous [Ca2+]i transients showed striking kinetic features and a sensitivity to external Ca2+ suggesting that they were the consequence of transient Ca2+ entries. Two kinetically distinct patterns of [Ca2+]i rises were generated in response to the two native forms of gonadotropin-releasing hormone (GnRH), salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II). In a part of the gonadotrophs, GnRHs triggered a plateau [Ca2+]i rise whereas in other responsive cells they induced a series of [Ca2+]i bursts, each consisting of grouped [Ca2+]i transients. Both plateau and burst [Ca2+]i response patterns were due to Ca2+ entry through plasma membrane Ca2+ channels, inasmuch as they were suppressed with external Ca2+ removal. No contribution of Ca2+ release from thapsigargin-sensitive stores was observed in either response pattern. While in mammalian gonadotrophs GnRH rises [Ca2+] by mostly acting on internal Ca2+ sequestering stores, our results show that GnRH-stimulated goldfish gonadotrophs ...Continue Reading

References

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Citations

Jul 24, 2010·Endocrine Reviews·Stanko S StojilkovicRichard Bertram
Oct 19, 2006·General and Comparative Endocrinology·Sheng-Hong Xu, Ian M Cooke
Dec 6, 2011·Cell Calcium·Stanko S Stojilkovic
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·James D JohnsonJohn P Chang
Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F E RebersR W Schulz

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