PMID: 8951935Oct 1, 1996Paper

Spontaneous and mechanically evoked afferent activity originating from myelinated fibres in ferret inferior alveolar nerve neuromas

Pain
U Bongenhielm, P P Robinson

Abstract

The inferior alveolar nerve is a predominantly sensory branch of the trigeminal nerve which runs within a bony canal, and is frequently damaged in patients. A small proportion of these patients develop neuropathic pain, and this may result from neural activity generated at the injury site. To investigate this abnormality we have used electrophysiological techniques in an animal model to determine the level of spontaneous activity and mechanical sensitivity of myelinated fibres ending in a neuroma of the inferior alveolar nerve. In 20 anaesthetised adult male ferrets the left inferior alveolar nerve was ligated in the region of the third premolar tooth, cut distally, and recovery permitted for periods of 3-113 days prior to making single unit recordings from the nerve central to the injury. The proportion of units which were spontaneously active ranged from 0% to 26%, with discharge rates 0.3-12.9 Hz. Discharge in response to mechanical stimulation of the neuroma was found in 0-36% of the units. Both spontaneous activity and mechanical sensitivity were significantly higher after shorter recovery periods and the majority of the spontaneously active units was also mechanically sensitive. These data reveal that the inferior alveola...Continue Reading

References

Dec 29, 1978·Brain Research·R Govrin-Lippmann, M Devor
Jul 1, 1977·The Journal of Investigative Dermatology·K W HorchP R Burgess
Aug 1, 1991·Journal of Neurocytology·K FriedM Devor
Jul 1, 1990·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·K D Hoffmann, M A Matthews
Nov 1, 1989·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·S J Lisney
Jan 1, 1988·Somatosensory & Motor Research·K Fried, M Devor
Jun 1, 1988·The British Journal of Oral & Maxillofacial Surgery·P P Robinson
Dec 1, 1984·Pain·H Blumberg, W Jänig
Mar 1, 1983·Journal of the Autonomic Nervous System·M Devor
Apr 1, 1981·Experimental Neurology·E M Korenman, M Devor
Feb 1, 1982·Journal of the Neurological Sciences·K Fried, C Hildebrand
Dec 11, 1981·Neuroscience Letters·B Nyström, K E Hagbarth
Jul 1, 1994·Journal of Neurophysiology·O Matzner, M Devor
Dec 10, 1993·Brain Research·R Amir, M Devor
Feb 1, 1996·The British Journal of Oral & Maxillofacial Surgery·P P Robinson, K G Smith

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Citations

Mar 19, 2003·Archives of Oral Biology·Leigh C AndersonRuth Veinote
Oct 21, 2004·Brain Research·Shelley L DaviesFiona M Boissonade
Jun 12, 2003·Archives of Oral Biology·E V BirdP P Robinson
Mar 18, 2006·European Journal of Pain : EJP·James E BiggsPeter P Robinson
Aug 2, 2000·The British Journal of Oral & Maxillofacial Surgery·P P RobinsonK G Smith
Aug 11, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·K FriedP P Robinson
Jul 1, 2004·The British Journal of Oral & Maxillofacial Surgery·Peter P RobinsonKeith G Smith
Jun 21, 2019·Molecular Pain·Diana Tavares-FerreiraFiona M Boissonade
Mar 22, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Mathilde SavignatPhilippe Libersa

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