Spontaneous and recurrent subdural haematoma in a patient with May-Hegglin anomaly.

BMJ Case Reports
John Anthony DohertyZaid Sarsam

Abstract

Both acute and chronic subdural haematomas typically occur following trauma. Non-traumatic causes are less common, but aetiologies include arteriovenous malformation, intracranial aneurysm rupture, tumour-associated haemorrhage and coagulopathies. May-Hegglin anomaly is an example of a coagulopathy, which is caused by a mutation in the gene encoding non-muscle myosin heavy chain 9 (MYH9) and therefore falls into a group of diseases referred to as MYH9-related diseases (MYH9-RD). The symptomology of MYH9-RD is often mild, and patients tend to experience epistaxis, gingival bleeding and bruising. Life-threatening haemorrhage rarely occurs. In this short report, we describe a patient with known May-Hegglin anomaly who presented with a potentially life-threatening, spontaneous subdural haematoma requiring surgery on two occasions. This is only the second such report in the literature, and the first of spontaneous and recurrent haemorrhage in association with May-Hegglin anomaly.

References

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Jul 27, 2005·American Journal of Hematology·Aasim S SehbaiVidya K Brown
Jun 27, 2009·Acta neurochirurgica·Ruediger GerlachKlaus Goerlinger
Apr 14, 2010·The Journal of Trauma·Beat SchnürigerDemetrios Demetriades
May 6, 2011·British Journal of Haematology·Carlo L BalduiniAnna Savoia
Jun 12, 2014·The Journal of Emergency Medicine·Jaron B CoombsEric J Chin
Dec 23, 2016·British Journal of Haematology·Lise J EstcourtUNKNOWN British Committee for Standards in Haematology
Jun 25, 2017·World Neurosurgery·Daphne LiG Alexander Jones
Sep 20, 2019·British Journal of Neurosurgery·Yoshinari OsadaTeiji Tominaga

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