Spontaneous and Stress-Induced Pore Formation in Membranes: Theory, Experiments and Simulations

The Journal of Membrane Biology
Edel Cunill-Semanat, Jesús Salgado

Abstract

The large plasticity, dynamics and adaptability of biological membranes allow different modes of intrinsic and inducible permeability. These phenomena are of physiological importance for a number of natural functions related to cell death and can also be manipulated artificially for practical purposes like gene transfer, drug delivery, prevention of infections or anticancer therapy. For these advances to develop in a controllable and specific way, we need a sufficient understanding of the membrane permeability phenomena. Since the formulation of early concepts of pore formation, there has been an enormous effort to describe membrane permeability by using theory, simulations and experiments. A major breakthrough has come recently through theoretical developments that allow building continuous trajectories of pore formation both in the absence and presence of stress conditions. The new model provides a coherent quantitative view of membrane permeabilization, useful to test the impact of known lipid properties, make predictions and postulate specific pore intermediates that can be studied by simulations. For example, this theory predicts unprecedented dependencies of the line tension on the pore radius and on applied lateral tensi...Continue Reading

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Citations

Oct 5, 2019·The Journal of Membrane Biology·Shikha Prakash, Durba Sengupta
Jun 5, 2020·European Biophysics Journal : EBJ·Md Kabir AhamedShareef Ahammed
Jun 15, 2020·European Biophysics Journal : EBJ·Mohammad Abu Sayem KaralShareef Ahammed
May 15, 2021·PloS One·Malay Kumar SarkarSayed Ul Alam Shibly
Nov 10, 2020·Journal of Chemical Theory and Computation·Marcelo CaparottaDiego Masone

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Methods Mentioned

BETA
transfection
optical fluorescence microscopy

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